Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot Study

Open-label, single-group pilot embedding a single IV ketamine infusion within a course of Mindfulness-Based Cognitive Therapy for adults with major depressive disorder (MADRS ≥20).

Primary aim is feasibility: whether the rapid antidepressant effect of ketamine facilitates engagement with MBCT and whether combined treatment is acceptable and safe; outcomes include depressive symptoms, tolerability, and retention.