Randomized, triple-blind Phase IV trial (n=200) testing a single IV ketamine 0.5 mg/kg infusion plus computer-based cognitive training versus sham training and treatment-as-usual in medically hospitalized suicidal patients.
This study evaluates the acute and longer-term impact of a single subanesthetic IV ketamine infusion (0.5 mg/kg) in suicidal medical inpatients and tests whether computer-based cognitive training (8 sessions) can extend ketamine's rapid effects.
Design: randomized, parallel-group, triple-masked, four-arm trial comparing ketamine with sham training, ketamine with active training, and TAU variants; primary aims focus on suicidality outcomes and trajectories over predefined time windows per registry clarifications.
Pooled open-label ketamine-treated sample from the published pilot; patients were randomized only to active versus sham cognitive training, which was pooled for analysis.
Brief automated cognitive training or sham training; groups pooled in the publication.