Ketamine + Cognitive Training for Suicidality in the Medical Setting

This study evaluates the acute and longer-term impact of a single subanesthetic IV ketamine infusion (0.5 mg/kg) in suicidal medical inpatients and tests whether computer-based cognitive training (8 sessions) can extend ketamine's rapid effects.

Design: randomized, parallel-group, triple-masked, four-arm trial comparing ketamine with sham training, ketamine with active training, and TAU variants; primary aims focus on suicidality outcomes and trajectories over predefined time windows per registry clarifications.