Ketamine for Depression: An MRI Study

Open-label, single-group study of 25 participants with major depressive disorder receiving a single IV infusion of ketamine (0.5 mg/kg over 40 minutes) with MRI before and after dosing.

Primary clinical outcome measured with the Hamilton Depression Rating Scale (HDRS); MRI data analysed to identify brain regions that predict antidepressant response.

Safety assessed with standard labs, vital signs, and EKG; healthy control cohort included for neuroimaging comparison.