Ketamine for Sedation in Severe Traumatic Brain Injury (Ketamine)

Open-label, randomized, parallel-group Phase IV trial comparing continuous IV ketamine added to propofol versus institutional standard-of-care analgosedation for adults with severe traumatic brain injury requiring intracranial pressure monitoring.

Experimental arm: propofol infusion (≈300 mcg/kg/hr) with ketamine infusion (1000–5000 mcg/kg/hr) and additional 2 mg/kg bolus for sustained ICP >22 mmHg; SOC arm receives local analgosedation per protocol. Safety, ICP control, and clinical outcomes assessed during hospital stay with one outpatient follow-up.