Ketamine Infusion Therapy for Australian Veterans with Treatment Resistant Depression and Post-Traumatic Stress Disorder
Open-label, interventional single-group study (n=100) delivering six IV ketamine infusions over two weeks (induction; 0.2–0.5 mg/kg initial titrated to 1.0 mg/kg; ~40 min per infusion) followed by up to six maintenance infusions every 3–6 weeks for Australian veterans with TRD and PTSD.
Details
This non‑randomised, open‑label study delivers an induction course of six intravenous ketamine infusions over two weeks (Mon/Wed/Fri) with doses set by the anaesthetist (initial 0.2–0.5 mg/kg, titrating to a maximum of 1.0 mg/kg) and each infusion administered over approximately 40 minutes.
Participants may receive up to six maintenance infusions every 3–6 weeks based on clinical response; infusions are delivered in a hospital setting by an anaesthetist with nursing monitoring during and for 60 minutes post‑infusion.
Outcomes include change in depression symptoms and suicidality measured at baseline, mid‑treatment and multiple follow‑up points up to approximately six months post‑induction.