Open-label, interventional single-group study (n=100) delivering six IV ketamine infusions over two weeks (induction; 0.2–0.5 mg/kg initial titrated to 1.0 mg/kg; ~40 min per infusion) followed by up to six maintenance infusions every 3–6 weeks for Australian veterans with TRD and PTSD.
This non‑randomised, open‑label study delivers an induction course of six intravenous ketamine infusions over two weeks (Mon/Wed/Fri) with doses set by the anaesthetist (initial 0.2–0.5 mg/kg, titrating to a maximum of 1.0 mg/kg) and each infusion administered over approximately 40 minutes.
Participants may receive up to six maintenance infusions every 3–6 weeks based on clinical response; infusions are delivered in a hospital setting by an anaesthetist with nursing monitoring during and for 60 minutes post‑infusion.
Outcomes include change in depression symptoms and suicidality measured at baseline, mid‑treatment and multiple follow‑up points up to approximately six months post‑induction.
Open-label single-group induction (6 infusions over 2 weeks) then up to 6 maintenance infusions (every 3–6 weeks) delivered IV in hospital by an anaesthetist.
Induction: six infusions (Mon/Wed/Fri) over 2 weeks; initial infusion 0.2–0.5 mg/kg (determined by anaesthetist) titrated to max 1.0 mg/kg; each infusion over ~40 minutes. Maintenance: up to six infusions delivered every 3–6 weeks based on clinical response.