Double-blind, randomised, parallel RCT (n=43) testing a single IV ketamine infusion (0.5 mg/kg over 40 min) with brief mindfulness training versus academic exercises in adults with unipolar depression.
Randomised, double-blind, parallel-group trial in adults with unipolar depression comparing a single intravenous ketamine infusion (0.5 mg/kg over 40 minutes) delivered with either brief mindfulness exercises or matched academic exercises.
Participants receive a 30‑minute preparatory session (mindfulness training or academic tasks) immediately prior to infusion; outcomes assess changes in depression scores following a single infusion.
Single IV ketamine infusion paired with brief mindfulness training immediately prior to infusion.
0.5 mg/kg over 40 minutes
30 min guided mindfulness training immediately prior to infusion
Single IV ketamine infusion paired with academic/mental-arithmetic exercises immediately prior to infusion.
0.5 mg/kg over 40 minutes
30 min academic cognitive exercises (mental math) immediately prior to infusion