Clinical TrialParallelOpioid Use Disorder (OUD)KetamineKetamineCompleted

Multiple vs Single Ketamine-Assisted Psychotherapy (KPT) for Heroin Dependence: Evaluator-Blind RCT (Krupitsky, St Petersburg Russia 2007)

This unregistered trial (n=59) was an evaluator-blind, randomised controlled trial of multiple versus single ketamine-assisted psychotherapy sessions for heroin dependence in detoxified adults, which found that repeated sessions significantly improved long-term abstinence rates.

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Target Enrollment
59 participants
Study Type
interventional
Design
Randomized, single Blind

Detailed Description

This synthetic trial has been added to our database because a psychedelic paper (about a clinical trial) references this trial, but no (live) registration can be found.

The study investigated whether repeated sessions of ketamine-assisted psychotherapy (KPT) provided greater benefits for heroin abstinence compared to a single session. Following inpatient detoxification, 59 participants were randomised to receive either three ketamine sessions (2.0 mg/kg IM) spaced one month apart with psychotherapy, or a single ketamine session followed by monthly addiction counselling.

At the twelve-month follow-up, survival analysis indicated that the multiple KPT group achieved a significantly higher rate of abstinence (50%) compared to the single KPT group (22.2%). While abstinence rates were improved, no significant differences were observed between the groups regarding depression, anxiety, heroin craving, or sense of purpose in life.

Study Arms & Interventions

Multiple KPT group

experimental

Three ketamine-assisted psychotherapy (KPT) sessions with one-month intervals, plus addiction counseling sessions before the second and third KPT sessions.

Interventions

  • Ketamine2 mg/kg
    via IM• three sessions at monthly intervals• 3 doses total

    Sessions were 1.5 to 2 hours long; accompanied by psychotherapy.

Single KPT group

experimental

One ketamine-assisted psychotherapy (KPT) session followed by two addiction counseling sessions at one-month intervals.

Interventions

  • Ketamine2 mg/kg
    via IM• single dose• 1 doses total

    Session was 1.5 to 2 hours long; accompanied by psychotherapy.

Study Protocol, Arms & Participants

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Study Details

Locations

Russia

Related Publications

Open AccessindividualPrimary

Single versus repeated sessions of ketamine-assisted psychotherapy for people with heroin dependence

This open-label longitudinal study (n=59) investigated the efficacy of a single versus three sessions of ketamine-assisted psychotherapy (140mg/70kg/session) for people with heroin dependence and found that the three-session program is more than twice as effective (abstinence 50% vs. 22.2%) one year after treatment.

Published
Journal
Journal of Psychoactive Drugs
Authors
Krupitsky, E. M., Burakov, A. M., Dunaevsky, I. V., Romanova, T. N., Slavina, T. Y., Grinenko, A. Y.

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