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LSD Occupancy of the Serotonin 2A Receptor in the Human Brain (dOccLS)

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Early‑Phase interventional dose-ranging study (n=40) assessing LSD single doses (25–200 µg) to quantify 5‑HT2A receptor occupancy in healthy participants using [11C]CIMBI‑36 PET/MR.

Details

Healthy participants (18–75 years) receive a single oral dose of LSD (one of 25–200 µg) in a single‑blinded, dose‑ranging design to characterise dose–plasma–receptor occupancy relationships.

Participants undergo baseline and two post‑dose [11C]CIMBI‑36 PET scans in a simultaneous PET/MR scanner at peak and declining effects; repeated venous sampling quantifies plasma LSD and repeated subjective intensity ratings (0–10) capture acute effects.

Topics:Healthy Volunteers

Registry

Registry linkNCT05953038