LSD Treatment for Persons With Alcohol Use Disorder (LYSTA)

This is a randomised, double-blind, active placebo-controlled parallel study in specialised addiction treatment centres in Switzerland evaluating LSD for the treatment of moderate to severe alcohol use disorder.

Participants receive two dosing days (treatment arm: 150 µg then 150 or 250 µg; comparator: 10 µg then 10 µg). The primary outcome is percent heavy drinking days at three months after administration; secondary objectives include neurobiological mechanisms.