MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD (MDMA-bCBCT)
Open-label single-group pilot (n=16 dyads, 8 PTSD+ veterans and their partners) testing MDMA-assisted bCBCT: 8-session therapy with two full-day MDMA sessions for PTSD+ veterans to evaluate preliminary effectiveness on PTSD and relationship functioning.
Details
Single-site, open-label pilot at VA San Diego Healthcare System evaluating MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy (bCBCT) in veterans with chronic PTSD and their intimate partners; total N=16 (8 dyads), with therapy delivered over approximately 7–13 weeks and follow-up to study completion.
PTSD+ veterans receive two full-day oral MDMA sessions (Session 1: 80 mg + 40 mg supplemental; Session 2: 100 mg + 40 mg supplemental). Partners attend sessions but do not receive MDMA. Preparatory, integration, telephone follow-ups, and emotion-focused integrative sessions support safety and integration.