An open-label, single-arm pilot study in Brazil investigating MDMA-assisted psychotherapy for adults with moderate-to-severe PTSD. Three participants received up to three MDMA sessions (75–125 mg) within a structured protocol of preparatory and integration therapy sessions, following the MAPS treatment model.
Participants received MDMA orally across three monthly sessions. Initial dose was 75 mg with an optional supplemental dose of 37.5 mg offered 90–120 min later. Dose could be escalated to 125 mg (with 62.5 mg supplement) in subsequent sessions. Each dosing session was flanked by preparatory and integration psychotherapy.
Supplemental dose of 50% the initial dose offered 90–120 min after initial administration (37.5 mg or 62.5 mg). Participants ultimately received total MDMA amounts of 112.5 mg and 187.5 mg across sessions.