MDMA Plus Exposure Therapy for PTSD

Open-label, single-group study of MDMA combined with massed Prolonged Exposure therapy in people meeting criteria for PTSD; a single Medicine Session with MDMA occurs on Day 2 of a 10-day PE programme.

Primary outcomes assess feasibility, safety and PTSD symptom change; exploratory psychophysiological and optional fMRI measures will probe mechanisms of treatment response. Participants are followed up at 1, 2 and 4 weeks and 6 months after treatment.