Modified Ketogenic Diet and Ketamine for Anorexia Nervosa
This open-label pilot study (n=5) aims to investigate whether a two-part outpatient procedure, utilising a modified ketogenic diet followed by a series of titrated ketamine infusions, can lead to improvements or remission of chronic anorexia nervosa in adults who have experienced symptoms for at least three years despite undergoing treatment involving at least two different modalities.
Details
Open-label, single-group pilot (n=5): participants complete a 2‑day immersive ketogenic diet education then 4 weeks of home diet adoption before receiving a series of titrated IV ketamine infusions over 2 weeks (starting 0.75 mg/kg, titrated up to 0.95 mg/kg; infusions ~45 minutes).
Safety and clinical response are assessed with objective and psychological measures during both parts and participants are followed for 12 months.