Music as an Adjunct to Ketamine Therapy for Chronic Pain (MusKiP)

Pragmatic randomised crossover trial recruiting 25 patients receiving repeated IV ketamine for chronic noncancer pain at the Alan Edwards Pain Management Unit. Each participant receives four one-hour infusions (baseline plus three conditions) of ketamine 0.5 mg/kg with randomized exposure to preferred music, therapist-selected music, or silence.

Outcomes include pain intensity and duration, mood, sleep, cognitive flexibility, and anxiety/depression symptoms; qualitative interviews will assess subjective ketamine experiences and any adverse effects. Sessions use noise-cancelling headphones and standardised ambient conditions to isolate music effects.