Clinical TrialChronic PainKetamineNot yet recruiting

Outcomes Registry After Ketamine Infusions for Chronic Pain: A Longitudinal Evaluation

This observational registry study (n=800) will examine adults with chronic pain who are planning to receive intravenous ketamine infusion therapy, along with a comparison cohort of patients who were recommended ketamine but did not receive it because of insurance denial. It will assess changes in pain interference over time, with additional aims to evaluate symptoms, function and possible ketamine-related craving or drug liking after treatment. Participants will complete an online survey a few days before the infusion and then weekly surveys for up to 16 weeks after treatment, or for up to 16 weeks from the originally scheduled treatment date in the denied-treatment cohort. The study will track pain, mood, sleep, medication use and other symptoms, and will compare outcomes between those who received ketamine and those denied coverage; optional medical record review is also mentioned.

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Target Enrollment
800 participants
Study Type
observational
Design
Non-randomized

Detailed Description

Ketamine is an anesthetic drug that is sometimes used to relieve chronic pain. The goal of this observational study is to learn about how patients respond to ketamine infusions for chronic pain.

Note: This study does not provide ketamine - instead, this study uses surveys to follow patients who are already scheduled to receive ketamine infusions as part of their regular medical care.

We will also follow a second group of patients who were recommended ketamine infusions by their doctor but were denied insurance coverage for this treatment. These participants will complete the same surveys for up to 16 weeks, starting from when their treatment was originally scheduled. Comparing this group to patients who received ketamine will help researchers better understand ketamine's effects and how insurance denials affect chronic pain patients.

Study Arms & Interventions

Ketamine Treated Cohort

Observational cohort of patients who received ketamine infusion therapy for the treatment of chronic pain

Interventions

  • Ketamine
    via IV• routine clinical care

Denied Treatment Cohort

Observational cohort of patients who were recommended ketamine infusion therapy but did not receive this treatment due to lack of insurance coverage

Participants

Ages
18 – ?
Sexes
Male & Female

Inclusion Criteria

  • Planning to receive an intravenous ketamine infusion for the treatment of chronic pain

Exclusion Criteria

  • Unable to read or understand English questionnaires

Study Details

  • Status
    Not yet recruiting
  • Type
    observational
  • Design
    Non-randomized
  • Target Enrollment800 participants
  • Timeline
    Start: 2026-08-01
    End: 2034-12-01
  • Compound
    Ketamine
  • Topic
    Chronic Pain

Study Team

Sponsors & Collaborators

Locations

Stanford Health Care — Stanford, California, United States