Persisting Effects of Psilocybin

This pilot, single-group basic science study administered a single oral psilocybin dose (25 mg per 70 kg) to healthy volunteers to investigate changes in emotion processing and neural circuitry that might predict repeated self-administration and inform mechanisms of abuse liability.

Participants were medically and psychiatrically screened, underwent ECG and laboratory testing, and were assessed with neuroimaging and behavioural measures pre- and post-administration; strict medication and substance-use exclusions applied.