Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State
This phenomenological exploration trial (n=15) aims to investigate the transient dissociative state induced by esketamine in patients with depressive disorder.
Details
This single‑group, basic‑science study uses an experiential phenomenological interview and the EQFC "Trait" questionnaire to explore the contents and structure of the transient dissociative state following routine esketamine treatment in patients with depressive disorder.
Participants are identified during routine esketamine sessions at the psychiatry department; consenting patients who experienced a transient dissociative state 2 days to 3 months after treatment undergo a recorded 45‑minute interview and questionnaire in a separate research consultation.
Findings will clarify the phenomenology of esketamine‑induced dissociation and inform therapeutic strategies to manage anxiety associated with dissociative experiences that may affect antidepressant response.