Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements (PREDICT)
This observational cohort study (n=540) aims to gather unified data from a large cohort of patients with Major Depressive Disorder (MDD) undergoing various treatment (including ketamine & esketamine) options to identify optimal biomarkers for depression treatments at the individual patient level.
Details
PREDICT is a prospective observational cohort collecting standardised TD-fNIRS (Kernel Flow2) and clinical data from adults starting treatment for MDD across separate cohorts: ketamine, esketamine (SPRAVATO), TMS, and antidepressant medication.
fNIRS measurements are taken at pre-treatment and at early- and post-treatment visits (timing varies by cohort). Data are observational only and will not influence clinical treatment decisions; the primary aim is to identify biomarkers predictive of individual treatment response.