Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone Detoxification

Methadone dependence is difficult to detoxify; this phase II randomised trial at Hospital Universitari Sant Joan evaluates whether repeated oral ibogaine administrations facilitate methadone tapering and detoxification.

Participants are randomised to a fixed regimen (six 100 mg doses) or an ascending regimen (100→600 mg over six administrations). Ibogaine is given when clinical opioid withdrawal appears; methadone is interrupted and reduced as specified.