Psilocybin-assisted Interpersonal and Social Rhythm Therapy for Depression

Single-arm, open-label feasibility study integrating interpersonal psychotherapy (IPT) with two supervised psilocybin dosing sessions for people with treatment‑resistant major depressive disorder.

The 10‑week intervention comprises three IPT preparation sessions, two dosing/debriefing sessions, five integration sessions, and follow-up at week 18; antidepressant discontinuation and safety monitoring (ECG, labs, urine drug and pregnancy tests) are supervised by consultant psychiatrists.