Psilocybin-assisted Treatment for Cannabis Use Disorder

This pilot, single-group study will test whether two supervised psilocybin sessions delivered within a 12-week counselling programme reduce cannabis use in 12 participants with Cannabis Use Disorder.

Participants complete four weekly preparatory meetings including a targeted CBT intervention, a psilocybin session (25 mg) in week 5 and a second session (25 mg or 35 mg) in week 7, with integration meetings and weekly follow-up through week 12 and assessments at 3 and 6 months.