Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder

This single-group, interventional Phase II study will enroll 15 US military Veterans with DSM-5 PTSD to evaluate safety and efficacy of psilocybin-assisted psychotherapy.

Participants receive preparatory therapy (up to 6–8 hours across up to 4 meetings), two psilocybin sessions (15 mg then 25 mg about two weeks apart; each session ≈8 hours, two facilitators), and post-session integration visits with follow-up to 6 months.