Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study

This single-arm, open-label proof-of-concept study assesses feasibility, safety, tolerability and preliminary efficacy of psilocybin-assisted psychotherapy for adults with moderate to severe Cannabis Use Disorder.

The 9‑week protocol includes eight motivational enhancement therapy/support sessions and two experimental psilocybin dosing sessions (25 mg each). Outcomes include cannabis use measures, safety, tolerability and feasibility metrics.