Psilocybin vs Ketamine for Alcohol Use Disorder (Psi vs Ket)

Parallel-group, double-blind randomised trial enrolling 80 participants with moderate–severe alcohol use disorder to compare efficacy and safety of a single 30 mg psilocybin session versus a single weight-based ketamine session (0.75 mg/kg), both delivered alongside individual psychotherapy.

Outcomes include alcohol consumption patterns (heavy drinking days), safety, and psychiatric measures; eligibility excludes recent hallucinogen/ketamine use, active suicidality, unstable medical conditions, and first-degree family history of psychotic disorders.