Psilocybin With Intracranial Neural Sensing (PINS)

This open-label, single-arm pilot study investigates neural, sensory, and cognitive effects of a single 10 mg oral dose of psilocybin in participants with chronic pain who already have implanted sensing-capable deep brain stimulation devices.

Outcomes include multi-site neural recording from ambulatory DBS devices, quantitative sensory and cognitive testing, and self-reported pain; hypotheses are changes in functional connectivity, reductions in clinical and task-based pain, and improved cognition.