Repeated Neurocognitive Measurements in Depressed Patients 2025

This project longitudinally tracks candidate neurobiological targets for depression and relates fluctuations in those targets to real-world functioning in people with unipolar depression.

In a nested ketamine subsample, participants receive a single open-label racemic ketamine infusion (0.5 mg/kg over 40 minutes) to assess acute modulation of those targets and associated cognitive and functional changes.