Single-group interventional study (n=20) conducting repeated neurocognitive and neurobiological measurements in unipolar depressed patients, with a ketamine substudy using a single 0.5 mg/kg IV infusion.
This project longitudinally tracks candidate neurobiological targets for depression and relates fluctuations in those targets to real-world functioning in people with unipolar depression.
In a nested ketamine subsample, participants receive a single open-label racemic ketamine infusion (0.5 mg/kg over 40 minutes) to assess acute modulation of those targets and associated cognitive and functional changes.
Open-label ketamine infusion (single group).
Racemic ketamine 0.5 mg/kg infused over 40 minutes (Ketalar).