Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort
This observational cohort study (n=20) aims to investigate the impact of a combined protocol of subanesthetic ketamine infusions (SKI) and bilateral cervical sympathetic blocks (CSB) on ageing in Special Operations Forces (SOF) members undergoing treatment for PTSD/TBI.
Details
The primary objective is to assess the impact of combined subanesthetic ketamine infusions and bilateral cervical sympathetic blocks on biological aging measured by the GrimAge epigenetic clock in SOF members with PTSD/TBI.
Secondary outcomes include changes in PTSD and mental health over six months using PCL-5, PHQ-9, DSI-SS, GAD-7, and NSI; tertiary objectives examine associations with free testosterone and C-reactive protein.
Prospective observational cohort of 20 SOF participants recruited at the Stella Center with clinical and biomarker assessments before and after the combined intervention protocol.