Clinical TrialKetamineCompleted

High-Dose IV Ketamine Infusion for Combat-Related PTSD in Veterans: Prospective Observational Case Series (Ross 2019, Ann Clin Psychiatry)

Prospective observational case series (Ann Clin Psychiatry 2019; Ross C, Jain R, Bonnett CJ, Wolfson P; PMID 31675388). Participants: 30 US military combat veterans (ages 18–75) with clinician-diagnosed combat-related PTSD. No control arm, no randomisation. Intervention: six 1-hour IV ketamine infusions over 2–3 weeks; first infusion at 1 mg/kg (max 60 mg), subsequent doses individually titrated to "psychotropic therapeutic response" (PTR). Outcomes: PCL-5 (PTSD) and PHQ-9 (depression) assessed pre-first and pre-sixth infusion. IRB-approved; written consent obtained. Design is explicitly described by authors as "observational case series". CT.gov: 0 hits; PubMed DataBankList empty.

Target Enrollment
30 participants
Study Type
interventional
Design
Non-randomized

Study Arms & Interventions

Ketamine infusion

experimental

A standard induction series of six 1-hour ketamine infusions, with doses adjusted to achieve a psychotropic therapeutic response (PTR).

Interventions

  • Ketamine1.94 mg/kg
    via IV• six 1-hour infusions over a 2-to 3-week period• 6 doses total

    First infusion began at 1 mg/kg (max 60 mg); subsequent doses were adjusted based on patient response to achieve PTR. Mean dose was 1.94 mg/kg.

Primary Results(1 publication)

Participants

N = 30C. et al. 2019 →

PCL-5

Score at Timepoint

Ketamine infusion—Day 21·C. et al. 2019 →

Adverse Events (from all publications)

Arm / GroupnAny TEAESevereSeriousDiscont.
Ketamine infusionexperimental30——0(0.0%)—

* The paper states 'none of the participants experienced any significant adverse events or significant vital sign abnormalities,' though it notes 'some occasional nausea'.

Study Details

  • Status
    Completed
  • Type
    interventional
  • Design
    Non-randomized
  • Target Enrollment30 participants
  • Timeline
    Start: 2017-01-01
    End: 2019-01-01
  • Compound
    Ketamine

Related Publications

High-dose ketamine infusion for the treatment of posttraumatic stress disorder in combat veterans.

Published
Authors
Ross, C., Jain, R., Bonnett, C. J., Wolfson, P. E.

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