Study of the Neural Circuits Underlying the Negative Emotional Bias of Depressive Disorders and Their Response to Ketamine (EMOKET)
Open-label interventional parallel study (n=96) comparing depressed patients treated with esketamine (Spravato) with healthy volunteers using fMRI emotional tasks, behavioural measures and biological profiling.
Details
This non-randomised parallel study will compare depressed patients receiving esketamine with healthy controls using fMRI emotional tasks and pupillometry to investigate neural circuits underlying negative emotional bias.
Assessments include tasks using validated image banks, behavioural measures of emotional valence, anatomical and functional MRI (~90 min), and biological investigations of immuno-inflammatory profiles and mRNA editing; clinical response measured by MADRS at 4 weeks with early change after dosing evaluated as a predictor.