The Impact of Ketamine on the Reward Circuitry of Suicidal Patients

Open-label diagnostic Phase III study using a single ketamine infusion to probe reward-circuitry and suicidal ideation in patients and including healthy control comparisons; neuroimaging (MRI) endpoints collected.

Primary aim is to characterise the neurobiology of suicidal thoughts independent of depression; clinical safety screening, ECG and lab monitoring, and follow-up per protocol.