The Role of HNKs in the Antidepressant Effect of Ketamine

Double-blind, randomised, parallel study in participants with current major depressive episodes comparing three single IV ketamine doses (0.3, 0.5, 0.7 mg/kg) to evaluate serum hydroxynorketamine (HNK) in relation to clinical change on HDRS, BDI and POMS.

MRI measures of glutamate and GABA are acquired before and during ketamine treatment to test whether acute neurotransmitter changes mediate antidepressant effects; primary purpose listed as basic science.