The UTHealth Ketamine Project

Open-label, single-group treatment study of 10 adults with treatment-resistant depression receiving serial slow IV ketamine infusions (0.5 mg/kg over 40 minutes).

Dosing schedule: twice weekly for 4 weeks then weekly for 4 weeks (12 total infusions). Primary outcome is remission based on depressive severity; a four-week observational follow-up will record clinical status and include a neurocognitive task.