Trifecta Research Study (Axial)

This observational study (n=52) will assess the impact of ibogaine-magnesium, 5-MeO-DMT, magnetic e-Resonance Therapy (MeRT), and physiological supplementation on post-traumatic stress disorder (PTSD), cognitive dysfunction, brain injury-related symptoms, depression, and suicidal ideation in Special Operations Forces combat veterans. It will examine whether these interventions, delivered in different sequences, are associated with improvements in PTSD symptoms and cognitive functioning over follow-up. Participants were assigned to one of two intervention sequences: physiological supplementation followed by MeRT and then ibogaine with magnesium and 5-MeO-DMT, or physiological supplementation followed by ibogaine with magnesium and 5-MeO-DMT and then MeRT. Ibogaine hydrochloride was given orally, with magnesium sulfate administered intravenously before ibogaine and orally each day; 5-MeO-DMT was inhaled as vapour using a pipe. Physiological supplementation could include synthetic testosterone, anastrozole, gonadorelin, vitamin and amino acid supplementation, fish oil, and ipamorelin. Outcomes included the PCL-5, Medical Outcomes Study Cognitive Functioning Scale, Stroop Squared Task, and an emotional free-recall task, with assessments reported up to 12 months and up to 15 weeks for the recall measure.