Understand dose-response and time course

The manuals converge on the need to understand how dose relates to the timing and intensity of psychedelic effects. Across the extracts, dosing is linked to observable changes in onset, peak, duration, and response, whether in 5-MeO-DMT, MDMA, or LSD. They also share an emphasis on monitoring the session course, with timing information used to support planning and assessment during the experience. Sources differ in how specifically they describe this time course and how dosing decisions are handled. The MDMA manual gives clear session landmarks, including onset at 30 to 60 minutes, peak effects at 70 to 90 minutes, and a later assessment point at about two and a half hours, plus criteria for a supplemental half-dose. The LSD source focuses more on oral and intravenous comparisons, noting plasma peak around 1.5 hours, subjective effects lasting roughly 8 to 12 hours, and differences between 75 μg IV, 100 μg oral, and 200 μg oral. The 5-MeO-DMT extract is less detailed on timing, but it does note variable intensity across patients and that treatment response may occur rapidly within approximately 2 hours.