Dosing

Informed consent, decisional capacity, autonomy, and withdrawal rights

Teaches how to obtain and maintain valid informed consent through clear disclosure, comprehension checks, capacity support, voluntariness, non-coercion, and respect for refusal or withdrawal. The competency also covers consent for screening procedures, recordings, collateral contact, rescue interventions, and documentation of the consent process.

4 roles · 59 guidelines · 0 courses · 0 providers

Confidentiality, privacy, and research data protection

Teaches protection of participant identity, sensitive clinical or occupational information, recordings, and research data. The competency covers coded identifiers, restricted access, secure handling, confidentiality safeguards, and privacy-preserving documentation.

5 roles · 53 guidelines · 0 courses · 0 providers

Screening, eligibility, and readiness assessment

Teaches how to assess clinical suitability before psychedelic or ketamine treatment, including medical and psychiatric screening, readiness evaluation, contraindication review, inclusion/exclusion criteria, and ongoing eligibility re-checks before dosing.

8 roles · 52 guidelines · 15 courses · 12 providers

Acute psychological response and emergency management during dosing

Cluster covering 35 related competencies for monitoring acute psychological effects, recognising and managing distress, crisis containment, emergency escalation, and rescue-medication coordination during psychedelic dosing sessions.

6 roles · 51 guidelines · 2 courses · 2 providers

Adverse event identification, documentation, and reporting

Teaches how to detect, elicit, document, and report adverse events and serious adverse events across the participant journey. The focus is accurate source documentation, regulatory reporting discipline, follow-up, and preservation of participant safety and trial integrity.

4 roles · 46 guidelines · 0 courses · 0 providers

Preparation and integration support

Cluster covering 31 related competencies including: Integration support, Integration therapy, Integration coaching.

7 roles · 43 guidelines · 18 courses · 14 providers

Suicide and serious psychiatric risk assessment

Teaches structured assessment of suicidal ideation, intent, psychiatric deterioration, and related high-risk presentations. Learners are trained to use appropriate tools, safety planning, emergency contacts, clinician access, and escalation pathways when risk is identified.

6 roles · 41 guidelines · 1 courses · 1 providers

Manual fidelity, protocol adherence, and deviation management

Teaches faithful delivery of manualized treatment and protocol-defined procedures while documenting and managing unavoidable deviations. The competency protects participant welfare, treatment consistency, data integrity, and sponsor oversight.

5 roles · 39 guidelines · 0 courses · 0 providers

Post-dose follow-up, safety monitoring, and retention support

Teaches ongoing participant contact after dosing to support stability, detect delayed adverse effects, maintain therapeutic containment, and sustain adherence to follow-up visits and outcome assessments.

5 roles · 37 guidelines · 0 courses · 0 providers

Discharge readiness, escort safety, and post-session supervision

Teaches how to determine when a participant is safe to leave after dosing and how to arrange appropriate supervision afterward. The competency covers psychological and physical stability, escort/support-person coordination, discharge restrictions, overnight or post-session support, and follow-up contact when needed.

4 roles · 30 guidelines · 0 courses · 0 providers

Emergency recognition, escalation, and disposition planning

Teaches recognition of medical or psychiatric emergencies and the steps required to escalate care safely. The competency includes de-escalation, clinical consultation, 911 or emergency department transfer, serious-event escalation, and referral to appropriate higher-level care.

7 roles · 29 guidelines · 3 courses · 3 providers

Blinding, allocation concealment, and unblinding control

Teaches how to preserve blinded trial conduct across participant interactions, outcome collection, staff roles, and session procedures. The competency includes preventing accidental unblinding, minimizing bias, and using emergency unblinding only when clinically necessary.

6 roles · 29 guidelines · 0 courses · 0 providers

Medication, substance-use, washout, and taper management

Teaches review and management of concomitant medications, restricted therapies, prohibited substances, washout periods, tapering requirements, and abstinence expectations. The competency includes participant counseling, medication reconciliation, sponsor notification, and team coordination when restrictions affect safety or interpretability.

5 roles · 29 guidelines · 0 courses · 0 providers

Study documentation, data integrity, and regulatory recordkeeping

Teaches accurate study documentation, source-record quality, secure data capture, Good Clinical Practice recordkeeping, IRB and sponsor documentation requirements, monitoring readiness, audit support, accountability, and retention obligations.

3 roles · 27 guidelines · 0 courses · 0 providers

Manualized psychedelic psychotherapy delivery

Teaches delivery of psychedelic-assisted psychotherapy according to an approved study manual across preparation, dosing, integration, and follow-up. The competency balances standardized structure with non-directive support for the participant’s therapeutic process.

4 roles · 25 guidelines · 3 courses · 2 providers

Therapeutic boundaries, professional conduct, and consent for touch

Teaches how to maintain clear relational and physical boundaries in emotionally vulnerable treatment settings. This includes professional conduct, rapport without overreach, explicit consent for touch, the right to revoke consent, and strict prohibition of sexual or erotic contact.

7 roles · 24 guidelines · 4 courses · 3 providers

Co-therapist and multidisciplinary team coordination

Teaches coordinated practice across co-therapists, physicians, psychiatrists, study coordinators, principal investigators, and other care-team members. The focus is shared responsibility, clear communication, role clarity, and coordinated observation of participant status.

4 roles · 24 guidelines · 0 courses · 0 providers

Physical safety monitoring

Cluster covering 3 related competencies including: Physical safety monitoring, Safety monitoring during dosing sessions, Medical safety monitoring during psilocybin administration.

5 roles · 19 guidelines · 0 courses · 0 providers

Acute psychiatric and behavioral risk monitoring

Teaches continuous monitoring for distress, confusion, psychotic symptoms, suicidality, agitation, and other acute behavioral risks during and after dosing. The focus is early recognition, documentation, and escalation to clinical support when risk emerges.

5 roles · 17 guidelines · 0 courses · 0 providers

Preparation support

Cluster covering 11 related competencies including: Preparation support, Psilocybin preparation, Therapeutic preparation.

3 roles · 16 guidelines · 6 courses · 5 providers

Ethical conduct in human-subject research

Able to practice ethically in a clinical trial environment involving a Schedule-sensitive psychoactive intervention. This includes protecting participants, adhering to protocol, and supporting valid informed participation.

3 roles · 16 guidelines · 0 courses · 0 providers

Supportive nondirective therapeutic stance

Cluster covering 6 related competencies including: Therapeutic support during dosing, Nondirective dosing-session presence, Supportive dosing-session facilitation.

2 roles · 16 guidelines · 0 courses · 0 providers

Therapeutic alliance building

Cluster covering 2 related competencies including: Therapeutic alliance building, Therapeutic alliance and rapport building.

2 roles · 15 guidelines · 1 courses · 1 providers

Good Clinical Practice and protocol procedure compliance

Teaches adherence to Good Clinical Practice, assigned study roles, protocol procedures, delegation boundaries, and applicable research regulations. The competency supports consistent execution of approved procedures across sites and participants.

4 roles · 15 guidelines · 0 courses · 0 providers

Psilocybin session facilitation

Cluster covering 9 related competencies including: Psilocybin facilitation, Psilocybin session support, Psilocybin facilitation basics.

6 roles · 14 guidelines · 6 courses · 5 providers

Adverse effects and side-effect management

Teaches recognition and management of expected and unexpected side effects during psychedelic or ketamine treatment. The competency emphasizes active observation, supportive response, and clinical escalation when symptoms exceed routine tolerability.

6 roles · 14 guidelines · 1 courses · 1 providers

Psychedelic-assisted psychotherapy preparation and integration

Teaches structured pre-dose preparation and post-dose integration as the therapeutic frame for psychedelic-assisted psychotherapy. The therapist supports rapport, intention clarification, meaning-making, emotional processing, and consolidation of insights after dosing.

6 roles · 13 guidelines · 2 courses · 2 providers

Hallucinogen pharmacology and effects

Cluster covering 7 related competencies including: Physiologic safety awareness, Hallucinogen pharmacology and effects, Hallucinogen-assisted therapy knowledge.

4 roles · 13 guidelines · 0 courses · 0 providers

Ketamine psychotherapy delivery

Cluster covering 12 related competencies including: KAP psychotherapy delivery, Ketamine and KAP knowledge, Ketamine integration planning.

6 roles · 12 guidelines · 7 courses · 5 providers

Dissociation and acute neuropsychiatric effect monitoring

Teaches recognition and documentation of dissociation, psychosis-like symptoms, mania, and other acute neuropsychiatric effects that can occur after ketamine, psychedelic dosing, or related interventions. The focus is monitoring, reporting, and escalation when symptoms become clinically significant.

5 roles · 12 guidelines · 0 courses · 0 providers

Physiologic monitoring, thermoregulation, hydration, and overdose response

Teaches monitoring and response for acute physiological risks, including vital signs, temperature, hydration, overheating, excessive fluid intake, and suspected overdose. The competency emphasizes supportive care, medical coordination, documentation, and escalation when needed.

6 roles · 11 guidelines · 0 courses · 0 providers

Special-interest adverse event vigilance

The protocol requires active monitoring for psychedelic-specific adverse events such as hallucinations, psychotic symptoms, dissociation, mood alteration, and cognitive disturbance. These require immediate notification and follow-up.

3 roles · 11 guidelines · 0 courses · 0 providers

Depression symptom and remission monitoring

Teaches structured monitoring of depressive symptoms, response, and remission across treatment and follow-up. Learners use standardized scales and clinical review to track change and identify deterioration or non-response.

2 roles · 10 guidelines · 0 courses · 0 providers

Mindfulness, intention-setting, set and setting, and somatic presence

Teaches practices that support preparation and therapeutic presence, including mindfulness, intention-setting, body-aware attention, environmental preparation, mindset awareness, and regulation through somatic presence.

6 roles · 9 guidelines · 7 courses · 6 providers

Trauma-informed therapeutic presence and somatic support

Teaches a trauma-informed stance during psychedelic work, including calm presence, non-verbal reassurance, body-aware support, somatic orientation, and containment through difficult experiences while maintaining safety and boundaries.

2 roles · 9 guidelines · 2 courses · 2 providers

Comprehensive psychiatric assessment

Ability to perform or supervise detailed psychiatric evaluation for diagnosis, eligibility, and ongoing monitoring. The therapist/facilitator must understand symptom presentations relevant to MDD, AUD, suicidality, psychosis, and dissociation.

3 roles · 9 guidelines · 0 courses · 0 providers

Grounding and regulation techniques

Therapists must be able to teach and coach grounding practices that help participants regulate during preparation and dosing. These methods are used before medication and during distress.

2 roles · 9 guidelines · 0 courses · 0 providers

Outcome Measure and Assessment Literacy

Teaches clinicians and research staff to understand the purpose, limits, scoring, interpretation, and clinical meaning of psychological measures and study instruments used to evaluate symptoms, functioning, safety, and treatment outcomes.

3 roles · 9 guidelines · 0 courses · 0 providers

Client preparation and therapeutic set/setting

Cluster covering 2 related competencies including: Preparation of set and setting, Client preparation and therapeutic set/setting.

3 roles · 8 guidelines · 2 courses · 2 providers

Continuation, discontinuation, and risk-benefit judgment

Teaches how clinicians determine whether a participant should proceed, pause, discontinue dosing, or terminate study participation. The competency centers on safety-driven clinical judgment, risk-benefit assessment, and early termination when continuation is no longer appropriate.

5 roles · 8 guidelines · 0 courses · 0 providers

Participant safety restriction counseling

Teaches how to instruct participants on post-dose and study-period restrictions that reduce risk from impaired judgment, unsafe activity, prohibited substances, or behaviors that could confound study outcomes.

3 roles · 8 guidelines · 0 courses · 0 providers

Physiologic monitoring during ketamine administration

Cluster covering 2 related competencies including: Safety monitoring during ketamine dosing, Physiologic monitoring during ketamine administration.

4 roles · 8 guidelines · 0 courses · 0 providers

Psychedelic-assisted therapy facilitation

Cluster covering 2 related competencies including: Psychedelic-assisted therapy facilitation, Group facilitation in a psychedelic setting.

3 roles · 8 guidelines · 0 courses · 0 providers

Psychological support during altered states

Provides supportive therapeutic presence while the patient is under the influence of ketamine. Uses calming, noncoercive guidance to help the patient navigate dissociation and emotional material.

3 roles · 8 guidelines · 0 courses · 0 providers

Use outcome assessment and follow-up to evaluate response

The study used standardized anxiety measures and followed patients for 2 months and 12 months, implying competence in tracking outcomes over time. Therapists should be able to assess symptom change and sustained benefit using structured follow-up.

2 roles · 8 guidelines · 0 courses · 0 providers

Vital sign and physical distress monitoring

Monitors participant physical status during study visits and identifies concerning changes requiring escalation. Vital signs and symptomatic changes are part of routine safety observation.

4 roles · 8 guidelines · 0 courses · 0 providers

Cultural humility, Indigenous respect, and equity-oriented care

Teaches culturally responsive psychedelic care, including humility, anti-bias practice, Indigenous and traditional-use awareness, cultural appropriation concerns, diversity and inclusion, and respectful work with marginalized communities.

6 roles · 7 guidelines · 11 courses · 10 providers

Transference, countertransference, and therapist self-awareness

Teaches recognition and management of relational dynamics that can intensify in psychedelic-assisted therapy. Learners develop self-awareness around countertransference, projection, attachment, dependency, and other therapeutic-process risks.

3 roles · 7 guidelines · 1 courses · 1 providers

Clinical Interviewing and PTSD Assessment

Teaches structured clinical interviewing and assessment administration for PTSD and related symptom domains, including symptom severity, functional impairment, risk factors, and appropriate use of standardized assessment tools.

2 roles · 7 guidelines · 0 courses · 0 providers

Dose escalation decision support

The therapist/facilitator must support structured dose escalation decisions within the individualized dosing regimen. Decisions depend on both patient-reported peak experience and clinical tolerability/safety judgments.

2 roles · 7 guidelines · 0 courses · 0 providers

Medical escalation and rescue medication coordination

Cluster covering 2 related competencies including: Medical escalation and rescue medication use, Medical escalation and rescue medication coordination.

4 roles · 7 guidelines · 0 courses · 0 providers

Safe Therapeutic Container Creation

Teaches providers to create and maintain a psychologically and physically safe therapeutic setting through clear structure, preparation, boundaries, attunement, environmental design, and ongoing attention to participant safety.

4 roles · 6 guidelines · 2 courses · 2 providers

Integration and post-session debriefing

Cluster covering 4 related competencies including: Integration and debriefing, Integration and debriefing facilitation, Integration and post-session debriefing.

2 roles · 6 guidelines · 0 courses · 0 providers

Ketamine infusion monitoring

Cluster covering 5 related competencies including: Cardiac safety monitoring, Ketamine infusion monitoring, Ketamine infusion administration.

3 roles · 6 guidelines · 0 courses · 0 providers

Medical screening and medication review

Therapists/investigators must understand the medical suitability requirements for LSD-assisted psychotherapy and coordinate medication washout and concomitant medication review. This includes recognizing drug-drug interaction risks and contraindications.

3 roles · 6 guidelines · 0 courses · 0 providers

Medication taper and withdrawal monitoring

Teaches monitoring during down-titration or discontinuation of psychiatric medications before dosing. Learners track withdrawal symptoms, symptom worsening, suicidality, and other risks that may emerge during tapering.

4 roles · 6 guidelines · 0 courses · 0 providers

Professional boundaries and recording consent

Therapists may record sessions only with explicit participant consent and must handle recordings for training and research within protocol limits. Recording is part of the therapeutic and scientific framework, not routine clinical use.

3 roles · 6 guidelines · 0 courses · 0 providers

Reproductive risk, contraception, and pregnancy monitoring

Teaches counseling and monitoring around contraception, reproductive restrictions, pregnancy risk, and pregnancy-related discontinuation rules. Learners are trained to explain requirements clearly and respond promptly when pregnancy or reproductive-safety concerns arise.

2 roles · 6 guidelines · 0 courses · 0 providers

Safe treatment-setting facilitation

Provide a calm and supportive environment during treatment to reduce distress and support tolerance of the experience. The case report notes food, rest, and a quiet place as part of care.

2 roles · 6 guidelines · 0 courses · 0 providers

Therapeutic rapport building

Cluster covering 4 related competencies including: Therapeutic rapport building, Rapport building and trust development, Therapeutic rapport and trust building.

2 roles · 6 guidelines · 0 courses · 0 providers

Psilocybin psychotherapy framework

Cluster covering 4 related competencies including: Psychedelic therapy workflow, Psilocybin psychotherapy framework, Psilocybin-assisted psychotherapy framework.

6 roles · 5 guidelines · 4 courses · 2 providers

Ethical psychedelic facilitation

Cluster covering 3 related competencies including: Ethical psychedelic facilitation, Safe, legal psychedelic care facilitation, Ethical decision-making in psychedelic facilitation.

7 roles · 5 guidelines · 2 courses · 2 providers

Session facilitation and therapeutic holding

Cluster covering 2 related competencies including: Session facilitation and therapeutic holding, Session facilitation and support during intense experiences.

3 roles · 5 guidelines · 2 courses · 2 providers

Management of concomitant medication interactions

Cluster covering 5 related competencies including: Concomitant medication review, Contraindication and interaction awareness, Contraindications, drug effects, and interactions.

4 roles · 5 guidelines · 1 courses · 1 providers

Assessment administration and interpretation

Ability to administer and interpret structured interviews, clinician ratings, and self-report measures used in the study. Therapists contribute to eligibility, safety, and outcome assessment.

2 roles · 5 guidelines · 0 courses · 0 providers

Evaluate clinically significant response and treatment outcomes

Therapists/facilitators should be able to judge whether therapeutic change reaches clinically meaningful thresholds, not just whether symptoms improve numerically. This supports informed ongoing care and communication about benefits and limitations.

2 roles · 5 guidelines · 0 courses · 0 providers

Match dose and setting to patient capacity

Therapists/facilitators need judgment about dosing and setting so experiences remain tolerable and therapeutically useful. The paper repeatedly notes that when dose and setting are appropriate, emerging material remains within the patient’s capacity to cope.

2 roles · 5 guidelines · 0 courses · 0 providers

Participant education and informed consent communication

Clinicians and research staff must clearly educate participants about study procedures, risks, side effects, restrictions, and possible benefits, and obtain written informed consent before screening and study participation. Ethical delivery depends on transparent communication and opportunities for questions.

2 roles · 5 guidelines · 0 courses · 0 providers

Participant safety planning and support network coordination

Can identify and involve support persons, attendants, and outside providers to enhance safety. The facilitator must coordinate practical supports while respecting confidentiality and protocol boundaries.

3 roles · 5 guidelines · 0 courses · 0 providers

Provide overnight and next-day containment

Therapists must ensure continuity of care after the acute session, including overnight observation and next-morning integration before discharge. This reflects a containment and recovery responsibility beyond the dosing period.

3 roles · 5 guidelines · 0 courses · 0 providers

Research assessment administration

Administer study measures and structured assessments on schedule, including psychological, spiritual, and neurobehavioral instruments. This includes both paper-based and Storyline-based assessments.

2 roles · 5 guidelines · 0 courses · 0 providers

Respect autonomy and individualized communication preferences

Adapt language and interpersonal style to the patient’s preferences to promote dignity and comfort. The therapist should also respect the patient’s autonomy within safety limits.

2 roles · 5 guidelines · 0 courses · 0 providers

Risk screening and exclusion judgment

Know the medical and psychiatric exclusions that protect participants from foreseeable harm. Facilitators must recognize conditions that make MDMA-assisted psychotherapy unsafe or inappropriate.

3 roles · 5 guidelines · 0 courses · 0 providers

Understand dose-response and time course

The facilitator should know how oral and intravenous dosing relate to onset, duration, and peak effects. This knowledge supports proper session planning, monitoring, and integration timing.

2 roles · 5 guidelines · 0 courses · 0 providers

Risk evaluation and safety monitoring

Teaches continuous evaluation of clinical risk and maintenance of a safe care environment throughout preparation, dosing, and follow-up. Learners monitor risk signals, apply safety procedures, and escalate care when needed.

6 roles · 4 guidelines · 3 courses · 2 providers

Music and therapist-variable awareness

The course explicitly mentions the role of music and therapist variables in treatment. Learners are expected to understand how these elements influence the PAP experience and therapeutic outcome.

3 roles · 4 guidelines · 1 courses · 1 providers

Therapeutic touch judgment

The training includes appropriate use of therapeutic touch as part of safe delivery. Learners are expected to use touch judiciously and within ethical boundaries.

4 roles · 4 guidelines · 1 courses · 1 providers

Controlled-substance handling awareness

Understands that MDMA is a Schedule 1 investigational product and must be stored, dispensed, and accounted for under regulatory control. Supports compliant handling during the session.

2 roles · 4 guidelines · 0 courses · 0 providers

Dosage judgment and administration safety

Competent facilitation requires practical knowledge of dosage ranges, initial dosing, boosters, formulation handling, and administration errors. The handbook stresses both clinical judgment and meticulous procedural care.

2 roles · 4 guidelines · 0 courses · 0 providers

Facilitate integration of experience into behavioral change

Cluster covering 2 related competencies including: Integration of psychedelic experience with behavior change, Facilitate integration of experience into behavioral change.

2 roles · 4 guidelines · 0 courses · 0 providers

Independent outcome assessment administration

The facilitator must administer and coordinate patient-rated and clinician-rated measures while minimizing bias. Assessments should be completed independently and in the correct order.

3 roles · 4 guidelines · 0 courses · 0 providers

Manage agitation and elopement risk

Respond to agitation or attempts to leave the room in a way that preserves safety for the patient and others. The therapist should use containment, redirection, and escalation protocols when needed.

3 roles · 4 guidelines · 0 courses · 0 providers

MDMA administration oversight

Study clinicians are responsible for administering study drug, ensuring correct dose assignment, and supervising safe oral ingestion during blinded sessions. This includes verifying visit-specific randomization information and ensuring dosing is delivered under the blinded workflow.

2 roles · 4 guidelines · 0 courses · 0 providers

Monitor acute and short-term adverse effects

The study emphasizes the absence of acute or chronic adverse effects persisting beyond 1 day and no treatment-related serious adverse events, indicating the need for active monitoring during and after treatment. Facilitators must be able to observe, document, and respond to adverse reactions.

2 roles · 4 guidelines · 0 courses · 0 providers

Narrative elicitation and phenomenological listening

Therapists must be able to elicit a full account of the dosing experience without overinterpreting it. The goal is to help participants remember, narrate, and reflect on their experience in detail.

2 roles · 4 guidelines · 0 courses · 0 providers

Pre-session dosing behavior instructions

Teaches clear communication of behavioral requirements before dosing sessions so conditions are standardized and preventable risks are reduced. Staff confirm that participants understand and follow pre-session instructions.

3 roles · 4 guidelines · 0 courses · 0 providers

Psilocybin psychoeducation

Cluster covering 2 related competencies including: Psilocybin psychoeducation, Psychedelic psychoeducation and expectation management.

2 roles · 4 guidelines · 0 courses · 0 providers

Recognition of contraindications and risk states

Therapists/facilitators must know the psychiatric and medical conditions that make KPT unsafe or inappropriate. Safe practice depends on excluding high-risk individuals.

2 roles · 4 guidelines · 0 courses · 0 providers

Structured symptom rating administration

Facilitators must competently administer and interpret clinician-rated ADHD and global severity measures. Accurate scoring is essential because these scales determine eligibility and outcomes.

3 roles · 4 guidelines · 0 courses · 0 providers

Substance use assessment

Ability to evaluate alcohol and other substance use patterns using standardized tools and clinical interview. This is essential for eligibility, safety, and outcome monitoring.

2 roles · 4 guidelines · 0 courses · 0 providers

Crisis and adverse-event response

The page signals training in managing difficult or high-risk moments, including crisis intervention and trigger management. Learners are expected to respond appropriately when a session becomes destabilizing or unsafe.

6 roles · 3 guidelines · 1 courses · 1 providers

Safety monitoring and emergency awareness

The page points to checklists and a guide to basic medical emergencies, indicating that learners should be able to monitor safety and recognize urgent issues. The overall training context also stresses keeping both client and practitioner safe.

5 roles · 3 guidelines · 1 courses · 1 providers

Assess outcomes and psychological change

The framework implies competence in evaluating both symptom change and subjective outcomes over time. The study used standardized anxiety measures and qualitative interviews to assess sustained effects and patient-reported change.

2 roles · 3 guidelines · 0 courses · 0 providers

Blinded Assessment and Independent Rating

Teaches the use of independent or blinded assessors to reduce expectancy and observer bias, preserve separation between therapeutic and rating roles, manage unblinding risks, and protect outcome validity in open-label or partially blinded designs.

3 roles · 3 guidelines · 0 courses · 0 providers

Cardiac risk monitoring

Monitor for ibogaine-associated cardiac toxicity, especially QTc prolongation and risk of torsades de pointes. This includes baseline exclusion screening, frequent ECG surveillance, and escalation when QTc becomes markedly prolonged.

2 roles · 3 guidelines · 0 courses · 0 providers

Elicit and formulate positive intentions

Help the patient identify personally meaningful, positive intentions to guide the session and future change. Intentions should be active, concrete, and framed toward desired gains rather than avoidance.

2 roles · 3 guidelines · 0 courses · 0 providers

Informed consent and treatment briefing

Therapists/facilitators must support ethically valid informed consent by ensuring participants understand the intervention, expectations, risks, and logistics. They also provide anticipatory guidance before ketamine sessions and discharge information after dosing.

2 roles · 3 guidelines · 0 courses · 0 providers

Informed consent responsibility

Facilitators are responsible for ensuring that participants have provided informed consent before receiving MDMA-assisted therapy. This reflects an ethical and regulatory duty central to work with investigational treatments.

2 roles · 3 guidelines · 0 courses · 0 providers

Informed preparation and orientation of the subject

The therapist is responsible for giving truthful, individualized preparation and reassurance about the experience, including likely sensations, risks of resistance, and expectations for conduct. The preparation aims to reduce fear, improve cooperation, and support voluntary participation.

2 roles · 3 guidelines · 0 courses · 0 providers

Interdisciplinary coordination across mental health and medical services

Combined ketamine infusion and PE treatment requires coordination between psychotherapy providers and medical/anesthesia or medication administration staff. Effective collaboration supports timing, safety oversight, and protocol fidelity.

3 roles · 3 guidelines · 0 courses · 0 providers

Knowledge of ayahuasca pharmacology and effects

Understand the basic pharmacology and clinical effects of ayahuasca to inform safe facilitation and interpretation of responses. The source identifies dimethyltryptamine as a 5-HT2A agonist and harmine as a monoamine-oxidase A inhibitor.

2 roles · 3 guidelines · 0 courses · 0 providers

Knowledge of MDMA effects and risks

Facilitators must understand the expected psychological, physiological, and potential adverse effects of MDMA in order to prepare participants, support the session, and detect complications.

3 roles · 3 guidelines · 0 courses · 0 providers

MRI safety screening and imaging-session coordination

Teaches screening for MRI contraindications and coordination of imaging clearance before scan procedures. The competency prevents exposure of ineligible participants to magnetic-resonance risks and supports safe imaging-session logistics.

3 roles · 3 guidelines · 0 courses · 0 providers

Opioid withdrawal assessment

Evaluates opioid withdrawal symptoms and tracks changes over time in participants discontinuing methadone OST. Uses standardized withdrawal ratings to assess potential treatment effects and safety.

2 roles · 3 guidelines · 0 courses · 0 providers

Pre-treatment clinical risk assessment

Understand the major medical risks associated with ibogaine administration, especially cardiac and neurologic toxicity, before proceeding with treatment. This includes recognizing that ibogaine has been linked to torsades de pointes, QTc prolongation, bradycardia, and ataxia.

3 roles · 3 guidelines · 0 courses · 0 providers

Psychoeducation about MDMA effects and session trajectory

Therapists must understand MDMA’s expected subjective, interpersonal, and physiological effects and prepare participants accordingly. This knowledge supports normalization, reassurance, and effective use of the medicine within therapy.

2 roles · 3 guidelines · 0 courses · 0 providers

Psychological preparation and anxiety reduction

Facilitators need practical skills in preparing participants emotionally for ketamine administration and reducing distress. The protocol highlights relaxation, breathing, and grounding strategies to reduce anxiety or discomfort associated with the drug experience.

2 roles · 3 guidelines · 0 courses · 0 providers

Psychological state assessment

Administer and interpret psychological and psychometric measures relevant to mood, cravings, expectations, mystical experience, ego dissolution, and functioning. Facilitators must accurately support questionnaire-based assessment across time points.

2 roles · 3 guidelines · 0 courses · 0 providers

Research rating fidelity

Ability to administer standardized clinical ratings consistently and under supervision. Reliable measurement is essential for efficacy and safety endpoints.

4 roles · 3 guidelines · 0 courses · 0 providers

Safety monitoring of vital signs and cardiovascular effects

Monitor and respond to the expected sympathomimetic effects of MDMA. The therapist/facilitator must be alert to transient increases in blood pressure, pulse, and related cardiac symptoms.

2 roles · 3 guidelines · 0 courses · 0 providers

Setting optimization

Create an environment that supports safety, comfort, and relaxation during the session. The setting is deliberately structured to reduce anxiety and facilitate a positive experience.

2 roles · 3 guidelines · 0 courses · 0 providers

Support safe administration of LSD dosing sessions

Because the protocol involved specific LSD doses, active placebo control, and session spacing, facilitators need applied skill in implementing dosing-session procedures safely and consistently. This includes maintaining therapeutic support while adhering to protocol constraints.

2 roles · 3 guidelines · 0 courses · 0 providers

Teach and apply stress inoculation and anxiety support

Therapists should identify or teach in-session coping tools and collaboratively plan how anxiety states will be recognized and supported.

2 roles · 3 guidelines · 0 courses · 0 providers

Therapeutic alliance and trust building

The therapist must create an atmosphere of confidence and mutual understanding before ketamine administration. This relationship is treated as a key therapeutic factor in the protocol.

1 role · 3 guidelines · 0 courses · 0 providers

Therapeutic rapport and engagement support

Help patients engage in emotionally intense trauma-focused treatment and reduce dropout risk. The therapist should recognize comorbid depression or anxiety that may interfere with adherence and response.

2 roles · 3 guidelines · 0 courses · 0 providers

Training and certification in study instruments

Teaches the requirement for site personnel to be trained and certified on protocol-specific assessments, psychiatric instruments, rating scales, and study procedures before performing them in the trial.

3 roles · 3 guidelines · 0 courses · 0 providers

Trauma treatment background

Therapists need a solid professional background in psychotherapy, especially PTSD treatment. Prior experience with established trauma therapies and related approaches is considered important preparation for this work.

2 roles · 3 guidelines · 0 courses · 0 providers

TRD eligibility assessment

Understands and applies the protocol-defined criteria for treatment-resistant major depressive disorder, including diagnostic confirmation, episode severity, and prior treatment failure requirements. Must verify both current and historical antidepressant nonresponse and ensure the participant remains eligible at baseline.

2 roles · 3 guidelines · 0 courses · 0 providers

Understanding of trial procedures and schedule

Know the sequence, timing, and purpose of screening, preparation, dosing, scanning, follow-up, and unblinding visits. The therapist/facilitator must be able to work within the full protocol structure.

2 roles · 3 guidelines · 0 courses · 0 providers

Harm reduction and risk awareness

Cluster covering 5 related competencies including: Harm-reduction orientation, Harm reduction and risk awareness, Harm reduction for client support.

7 roles · 2 guidelines · 5 courses · 5 providers

Dosing-day facilitation

Cluster covering 2 related competencies including: Dosing-day facilitation, Dosing-session facilitation.

4 roles · 2 guidelines · 2 courses · 2 providers

Legal and Regulatory Navigation

Teaches practitioners to identify and apply relevant legal, regulatory, ethical, and institutional requirements, including documentation, consent, reporting, controlled-substance, and jurisdiction-specific obligations.

6 roles · 2 guidelines · 2 courses · 2 providers

Guided inquiry and reflective language

Students learn to use language and questions that deepen a client’s inner experience and support healing. This is a practical communication competency for facilitation and integration work.

2 roles · 2 guidelines · 1 courses · 1 providers

ACT-based case formulation

Therapists must understand participant distress through an Acceptance and Commitment Therapy lens and use that formulation throughout preparation, dosing, and integration. They identify psychological inflexibility processes and track movement toward or away from psychological flexibility.

1 role · 2 guidelines · 0 courses · 0 providers

Assess and engage support systems

Therapists should understand the participant’s support network and appropriately involve support persons when relevant and desired.

2 roles · 2 guidelines · 0 courses · 0 providers

Assessment of indications and contraindications

The therapist must exercise clinical judgment about who may benefit, who may have difficulty surrendering defenses, and where evidence is limited. The handbook emphasizes uncertainty, need for research, and cautious selection based on insecurity, rigidity, suspicion, diagnosis, and treatment goals.

2 roles · 2 guidelines · 0 courses · 0 providers

Assessment-driven therapeutic tailoring

Uses assessment findings to individualize therapy and medication-session preparation. Adapts the approach based on participant response, goals, and clinical presentation.

1 role · 2 guidelines · 0 courses · 0 providers

Baseline history taking

Collect and interpret baseline behavioral, psychiatric, and medical history relevant to psilocybin research. This information is used to determine eligibility and contextualize outcomes.

2 roles · 2 guidelines · 0 courses · 0 providers

Ceremonial framing and intentional therapeutic setting

Facilitators require skill in establishing ceremonial and intentional framing around ketamine sessions to support therapeutic depth and coherence. This includes preparing participants for the significance and structure of the experience within the group model.

1 role · 2 guidelines · 0 courses · 0 providers

Cognitive safety monitoring

Ability to monitor for short-term cognitive impairment following psychedelic administration. The study included tests designed to detect decrements in attention and processing speed.

2 roles · 2 guidelines · 0 courses · 0 providers

Collaboration with medical supervision

Therapists function within a medically supervised ketamine model and must coordinate closely with clinicians responsible for dosing oversight and safety clearance. This includes understanding role boundaries and supporting monitoring workflows.

3 roles · 2 guidelines · 0 courses · 0 providers

Competence in protocol adherence for dosing sessions

The intervention involved two separate psilocybin dosing sessions 3 weeks apart under a randomized controlled protocol, implying the need for facilitators to reliably support treatment according to a fixed schedule and study procedures.

2 roles · 2 guidelines · 0 courses · 0 providers

Confidential and nonjudgmental therapeutic stance

Facilitators should create a safe interpersonal environment conducive to disclosure and processing. The setting is intentionally designed to support openness, comfort, and trust.

2 roles · 2 guidelines · 0 courses · 0 providers

Deliver mindfulness and grounding exercises

Use brief mindfulness practices and grounding strategies to stabilize attention and reduce distress before and during the session. These techniques help the patient reconnect to present-moment awareness and bodily sensation.

2 roles · 2 guidelines · 0 courses · 0 providers

Manage mandated reporting and safety concerns

Therapists/facilitators must fulfill professional legal duties and escalate safety or reporting concerns promptly.

2 roles · 2 guidelines · 0 courses · 0 providers

Medication conversion and detoxification workflow

Coordinate the conversion from opioid maintenance treatment to morphine-sulphate prior to ibogaine dosing, reflecting the treatment sequence described in the study. This requires careful timing and clinical oversight.

2 roles · 2 guidelines · 0 courses · 0 providers

Nasal tolerability assessment

Performs targeted nasal examinations and assesses local tolerability of esketamine nasal spray. Identifies findings that could affect drug delivery, safety, or continuation.

2 roles · 2 guidelines · 0 courses · 0 providers

Nausea and vomiting management

Recognize and respond to gastrointestinal adverse effects that may occur frequently with higher doses. Manage emesis to reduce aspiration risk, dehydration, and treatment disruption.

2 roles · 2 guidelines · 0 courses · 0 providers

Nighttime and overnight participant support

When overnight stays are required, facilitators and attendants must maintain safe observation and supportive presence without acting as outside therapists. They need to monitor comfort, safety, and emergency access overnight.

2 roles · 2 guidelines · 0 courses · 0 providers

Non-responder handoff and continuity of care

The facilitator must ensure non-responders are transitioned safely back to clinical care. Continuity of care is explicitly required to support ongoing psychiatric treatment.

2 roles · 2 guidelines · 0 courses · 0 providers

Outcome and safety measure literacy

Knowledge of the trial’s primary, secondary, and exploratory endpoints and the instruments used to assess them. This enables accurate administration and interpretation of study procedures.

2 roles · 2 guidelines · 0 courses · 0 providers

Patient monitoring during ibogaine administration

Monitors patients closely during treatment because serious adverse outcomes may occur. Safety monitoring is essential given that one participant died during treatment in the study.

2 roles · 2 guidelines · 0 courses · 0 providers

Peak experience assessment

Ability to assess whether the target acute psychedelic experience has occurred using the study-defined scale and threshold. This was used to guide individualized dosing.

2 roles · 2 guidelines · 0 courses · 0 providers

Pharmacokinetic awareness

Understands the drug’s rapid absorption profile and lack of accumulation with repeated dosing. Uses this knowledge to anticipate timing of effects and safety observations.

2 roles · 2 guidelines · 0 courses · 0 providers

Preparation for altered-state experience

A major therapist competency is preparing patients extensively for the ketamine session, including the nature of the special state of consciousness and possible ego dissolution or separation from the body. Preparation is both educational and psychotherapeutic.

1 role · 2 guidelines · 0 courses · 0 providers

Professional licensure and supervision

Therapists must meet licensure requirements and work within supervision structures appropriate to their training and role. Unlicensed or PAP-inexperienced staff require direct supervision.

2 roles · 2 guidelines · 0 courses · 0 providers

Protocol adherence and visit scheduling

Ability to manage the study schedule, windows, and follow-up procedures accurately. This supports treatment delivery and valid outcome collection.

2 roles · 2 guidelines · 0 courses · 0 providers

Relapse prevention psychotherapy delivery

Deliver ongoing relapse prevention psychotherapy after dosing through the post-dose follow-up period. The approach is used to support alcohol recovery and translate treatment effects into behavior change.

1 role · 2 guidelines · 0 courses · 0 providers

Retention and engagement skills

Given the risk of high attrition, facilitators need strong engagement and follow-up skills. The protocol explicitly notes the importance of respecting time commitments, tracking procedures, and strong interpersonal skills of study personnel.

1 role · 2 guidelines · 0 courses · 0 providers

Safety monitoring for adverse effects

Monitors for potential adverse effects associated with ibogaine administration and the detoxification period, even though the abstract primarily reports outcomes rather than specific events.

2 roles · 2 guidelines · 0 courses · 0 providers

Session pacing and timing

Therapists must pace the day appropriately, from early dosing to flexible termination, avoiding premature ending that could destabilize the subject. The handbook presents timing as an active facilitative skill rather than a logistical detail.

2 roles · 2 guidelines · 0 courses · 0 providers

Shared decision-making and referral coordination

Collaborates with patients, medical practitioners, and referring providers to support individualized care. Helps patients consider alternatives and coordinate ongoing treatment needs.

3 roles · 2 guidelines · 0 courses · 0 providers

Track cognitive performance during treatment

Because cognitive performance during treatment is a named secondary outcome, clinicians involved in care should be able to monitor and document cognitive functioning relevant to treatment participation. This supports safety oversight and interpretation of treatment effects.

2 roles · 2 guidelines · 0 courses · 0 providers

Understanding MDMA effects and non-linear healing

Therapists must have a thorough understanding of MDMA’s subjective, relational, and physiological effects, including the non-linear way these may support healing. This knowledge is necessary for preparation, in-session decisions, and normalization of participant experiences.

2 roles · 2 guidelines · 0 courses · 0 providers

Use of ACT and adjunctive psychotherapies

Apply Acceptance and Commitment Therapy as the primary psychotherapeutic framework, while using other modalities as clinically indicated. The protocol also references CBT, psychodynamic approaches, and Internal Family Systems.

1 role · 2 guidelines · 0 courses · 0 providers

Use of structured rating scales

The therapist/facilitator or designated rater must administer and interpret multiple structured clinical scales reliably. Training and separation of roles are required to preserve rating quality and blinding.

3 roles · 2 guidelines · 0 courses · 0 providers

Values clarification and committed action coaching

Therapists must help participants identify, recover, and translate values into concrete behavior change. The manual treats values work as central to depression recovery and integration.

2 roles · 2 guidelines · 0 courses · 0 providers

Withdrawal symptom assessment

Measure opioid withdrawal severity using standardized instruments and interpret symptom severity over time. Facilitators must be able to collect both objective observation and patient-reported data.

2 roles · 2 guidelines · 0 courses · 0 providers

Work within medically supervised settings

LSD-assisted psychotherapy in this study is explicitly framed as medically supervised. Therapists/facilitators need to practice within a setting capable of medical oversight and management of prolonged altered states.

4 roles · 2 guidelines · 0 courses · 0 providers

Trauma-informed care

Cluster covering 2 related competencies including: Trauma-informed care, Trauma-informed psychedelic care.

4 roles · 1 guidelines · 4 courses · 4 providers

Psychedelic integration support

Cluster covering 2 related competencies including: Psychedelic integration support, Psychedelic knowledge integration.

4 roles · 1 guidelines · 2 courses · 2 providers

Psychotherapeutic facilitation methods

Cluster covering 2 related competencies including: Facilitation of psychedelic journeys, Psychotherapeutic facilitation methods.

4 roles · 1 guidelines · 2 courses · 2 providers

Trauma-informed practice

Cluster covering 2 related competencies including: Trauma-informed practice, Trauma-informed clinical practice.

2 roles · 1 guidelines · 2 courses · 1 providers

Accurate source limitation recognition

Ability to acknowledge when the source does not contain therapist or facilitator competency information. The extractor should not overstate what can be supported by the text.

2 roles · 1 guidelines · 0 courses · 0 providers

Acute monitoring of subjective intensity

Track the participant’s subjective drug intensity during the active phase of the session. This includes recognizing when the participant cannot respond and how to document maximum intensity.

2 roles · 1 guidelines · 0 courses · 0 providers

Administration of vaporized 5-MeO-DMT

Ability to correctly deliver the investigational inhaled drug using standardized vaporization procedures and participant instructions. Safe and accurate administration is central to the dosing protocol.

2 roles · 1 guidelines · 0 courses · 0 providers

Alcohol abstinence screening and enforcement

Ensure required abstinence conditions are met before dosing and make clinical judgments about rescheduling or exclusion when they are not. This protects safety and protocol integrity.

2 roles · 1 guidelines · 0 courses · 0 providers

Assessment administration and sequencing

Administer study assessments in the correct order and in the correct format. The protocol depends on reliable, standardized administration by trained site personnel and central raters.

1 role · 1 guidelines · 0 courses · 0 providers

Assessment of psychological readiness and vulnerability

Before administration, facilitators should assess readiness and factors that could increase the chance of a difficult session. The source highlights that preoccupation, rigidity, low trust, and poor support can worsen experiences.

2 roles · 1 guidelines · 0 courses · 0 providers

Assessment of treatment response

Track onset, duration, and phases of ibogaine effects as part of clinical monitoring. The manual describes multiple stages of effect and expects the provider to observe them carefully.

2 roles · 1 guidelines · 0 courses · 0 providers

Ataxia and neurologic monitoring

Assess for cerebellar adverse effects such as ataxia during and after ibogaine administration. The source indicates ataxia is likely driven by ibogaine exposure and should be tracked systematically.

2 roles · 1 guidelines · 0 courses · 0 providers

Ayahuasca pharmacology and dosing awareness

Facilitators need basic knowledge of ayahuasca composition, dosing, and interaction risks to support safe administration. The protocol emphasizes dose calculation, substance composition, and monitoring for contraindications.

1 role · 1 guidelines · 0 courses · 0 providers

Behavioral assessment administration

Trained staff must administer and/or supervise a battery of behavioral tasks and self-report instruments consistently across baseline and drug sessions. Some measures are verbally administered by clinicians or coordinators and require standardized delivery.

2 roles · 1 guidelines · 0 courses · 0 providers

Boundary management in a dual-role therapeutic model

Navigate the combination of psychedelic support and AUD therapy while preserving clear therapeutic boundaries. The facilitator must deliver supportive care without role confusion or undue influence.

2 roles · 1 guidelines · 0 courses · 0 providers

Check-in and timing of interventions during sessions

Therapists must skillfully time check-ins and interventions to sustain process without unnecessary intrusion. They monitor silence, talking, avoidance, and signs of internal engagement to decide when to inquire, redirect, or simply witness.

2 roles · 1 guidelines · 0 courses · 0 providers

Clinical judgment for exclusion of high-risk patients

Exclude or defer patients whose medical risk is too high, especially those with cardiovascular disease or other major contraindications. This is central to safer administration according to the source.

2 roles · 1 guidelines · 0 courses · 0 providers

Clinical judgment on treatment optimization

Uses observed patient response to help optimize how ketamine-assisted psychotherapy is administered. Informs future clinical decisions about approach and dosing strategy.

2 roles · 1 guidelines · 0 courses · 0 providers

Clinician therapist availability and scope

At least one therapist in the dyad must be a clinician with capability to assess and manage medical or psychiatric adverse events during the dosing session. This reflects a required competency boundary between general support and clinical responsibility.

2 roles · 1 guidelines · 0 courses · 0 providers

Collaboration with medical and nursing staff

Ketamine-assisted treatment in this protocol is multidisciplinary, so facilitators must work closely with study doctors and nurses. This includes coordinating preparation, understanding monitoring responsibilities, and escalating concerns appropriately.

1 role · 1 guidelines · 0 courses · 0 providers

Controlled inhalation administration

Can safely administer vaporized GH001 using standardized equipment and procedure. Accurate delivery and participant instruction are essential to reliable dosing.

2 roles · 1 guidelines · 0 courses · 0 providers

Coordinate adjunctive ketamine or active placebo with psychotherapy timing

Facilitators and treating clinicians must understand and operationalize the study-specific timing between infusions and exposure sessions. This includes aligning infusion administration 24 hours before PE sessions during the first 3 weeks.

1 role · 1 guidelines · 0 courses · 0 providers

COVID-19 infection control

Implement infection-prevention procedures during in-person study and dosing visits. Facilitators must screen participants, use PPE, maintain distancing when feasible, and adapt procedures based on test results or symptoms.

2 roles · 1 guidelines · 0 courses · 0 providers

CYP2D6 genotype-informed dosing

Use pharmacogenetic information to anticipate altered ibogaine metabolism and exposure. The study identifies CYP2D6 activity as a major determinant of ibogaine clearance.

2 roles · 1 guidelines · 0 courses · 0 providers

Documentation and note-taking

Document participant experiences and relevant observations to support continuity, recall, and study integrity. Notes may also serve as a participant memory aid after dosing sessions.

2 roles · 1 guidelines · 0 courses · 0 providers

Documentation of subjective experience

The therapist/facilitator must record participant-reported effects and clinically relevant observations accurately. Documentation supports both safety monitoring and outcome interpretation.

2 roles · 1 guidelines · 0 courses · 0 providers

Dose selection and regimen planning

Plan ibogaine dosing based on patient status, formulation, prior opioid exposure, and therapeutic goals. The manual presents both single-dose and multi-dose approaches and stresses patient-specific judgment.

1 role · 1 guidelines · 0 courses · 0 providers

Dose-response observation

Tracks dose-dependent changes without assuming full psychedelic effects. This includes recognizing that low-dose exposure may modulate brain activity while remaining sub-psychedelic.

2 roles · 1 guidelines · 0 courses · 0 providers

Drug interaction and mechanism awareness

Understand the role of serotonergic mechanisms and the implications of receptor antagonism for acute psychedelic effects. Use this knowledge to interpret responses and co-administration effects.

2 roles · 1 guidelines · 0 courses · 0 providers

Electrolyte and medical screening

Assess for physiologic factors that may increase ibogaine-related harm, especially electrolyte abnormalities. The source identifies electrolyte screening as part of safer administration.

2 roles · 1 guidelines · 0 courses · 0 providers

Escitalopram monitoring and counseling

Understand the common and serious adverse effects, interaction risks, and monitoring needs of escitalopram. This includes cardiac, psychiatric, sexual, and withdrawal-related concerns.

2 roles · 1 guidelines · 0 courses · 0 providers

Ethical supervision in experimental drug administration

Ensure that administration occurs within an ethically supervised research or clinical framework with informed oversight and careful risk-benefit consideration. Hallucinogenic agents require especially cautious use in vulnerable psychiatric populations.

1 role · 1 guidelines · 0 courses · 0 providers

Hydration management

Prevent dehydration during and after ibogaine treatment. The manual stresses that patients may not feel like drinking and that dehydration can become dangerous, especially if vomiting occurs.

2 roles · 1 guidelines · 0 courses · 0 providers

Ibogaine treatment administration knowledge

Knows the use of ibogaine as a detoxification agent in medical and nonmedical settings and understands that its mechanism of action is novel and not fully established.

2 roles · 1 guidelines · 0 courses · 0 providers

Ibogaine-specific cardiac vigilance

Understand the unique cardiovascular hazards associated with ibogaine and the need for intensive cardiac oversight. The facilitator should know that cardiac risk is a central safety issue rather than a minor side effect.

3 roles · 1 guidelines · 0 courses · 0 providers

In-session emotional support

During ketamine administration, the therapist provides continuous emotional support while the patient reclines with eyeshades and music. This support helps the patient tolerate and make use of the psychedelic experience.

1 role · 1 guidelines · 0 courses · 0 providers

Informed consent administration

Therapists/facilitators must ensure participants are properly informed using approved consent materials before participation in MDMA-assisted psychotherapy research.

2 roles · 1 guidelines · 0 courses · 0 providers

Informed consent and ethical use in uncertain evidence

Use ibogaine only after a careful discussion of uncertain efficacy, limited research, and known risks. Ethical practice requires transparent communication about the experimental nature of treatment and the absence of robust clinical standards.

2 roles · 1 guidelines · 0 courses · 0 providers

Informed oversight for vulnerable participants

Exercises heightened ethical responsibility when working with people with opioid dependence undergoing medication changes. Ensures participation remains voluntary, monitored, and clinically appropriate.

1 role · 1 guidelines · 0 courses · 0 providers

Interpretation of neuroimaging-linked clinical findings

Understand that changes in cerebral blood flow were observed after ayahuasca intake in regions implicated in mood and emotion regulation. Facilitators should be able to contextualize these findings without overinterpreting them clinically.

2 roles · 1 guidelines · 0 courses · 0 providers

Knowledge of psychedelic session structure

Facilitators need to understand the full treatment sequence and how each phase contributes to safety and treatment delivery. The intervention depends on correct sequencing and timing.

2 roles · 1 guidelines · 0 courses · 0 providers

Knowledge of therapeutic mechanism and expected time course

The therapist/facilitator should know the expected onset, peak, and persistence of effects to guide monitoring and interpretation. The source reports acute effects with follow-up improvements lasting days.

2 roles · 1 guidelines · 0 courses · 0 providers

LSD psychotherapy administration

Ability to administer LSD in a psychotherapy setting using the regimen described in the source. The therapist/facilitator must understand session-based dosing and treatment course structure.

2 roles · 1 guidelines · 0 courses · 0 providers

Maintain a post-session safety net

Therapists must provide continuity, availability, and clear support structures after MDMA sessions to reduce anxiety and manage emerging difficulties. This safety net extends beyond the dosing day.

2 roles · 1 guidelines · 0 courses · 0 providers

Management of dual relationships and undue influence

Therapists must protect voluntariness when potential participants are also their patients. Independent evaluation should be used to reduce pressure or perceived coercion in recruitment and consent.

2 roles · 1 guidelines · 0 courses · 0 providers

Management of hypertension and cardiovascular complications

Therapists in this setting must recognize abnormal cardiovascular responses and follow protocolized responses for hypertensive crisis, angina, myocardial infarction, or stroke.

2 roles · 1 guidelines · 0 courses · 0 providers

Management of psychological distress

Facilitators must be able to contain and support intense psychological distress during the session. The study notes that the experience could be emotionally difficult even when participants felt safe.

2 roles · 1 guidelines · 0 courses · 0 providers

Managing short-duration high-intensity sessions

5-MeO-DMT produces a very short but intense experience, which changes facilitation demands. Facilitators must be prepared for rapid transitions into and out of the altered state.

1 role · 1 guidelines · 0 courses · 0 providers

Medical contraindication screening

Recognizes medical factors that may increase risk during inhaled 5-MeO-DMT administration. Medical clearance is required before dosing.

2 roles · 1 guidelines · 0 courses · 0 providers

Medication reconciliation and interaction management

Therapists must understand clinically significant drug interactions with ibogaine, including QT-prolonging, serotonergic, centrally acting, and CYP2D6-related medications. This knowledge informs screening, tapering, and dosing decisions.

2 roles · 1 guidelines · 0 courses · 0 providers

Monitoring and documentation of device-related issues

Because study drug delivery uses a vaporization device, staff must be able to recognize, document, and escalate device deficiencies. Device issues may have safety implications even when no patient harm occurs.

2 roles · 1 guidelines · 0 courses · 0 providers

Nasal administration awareness

Understand the intranasal administration procedure and related local adverse effects. The facilitator must support safe delivery and monitor nasal reactions.

1 role · 1 guidelines · 0 courses · 0 providers

On-site physician emergency competence

A study physician with psychiatric and cardiovascular emergency expertise must be available during dosing. This reflects a requirement for advanced emergency readiness and clinical judgment.

1 role · 1 guidelines · 0 courses · 0 providers

Ongoing informed consent

Treat consent as a continuing process rather than a one-time event. Patients must understand the treatment and retain the ability to revoke consent, with special procedures during the medication session for safety.

2 roles · 1 guidelines · 0 courses · 0 providers

Operational prioritization of assessments

Sequences study procedures correctly to reduce bias and protect participant safety. Particularly prioritizes PROs, clinician ratings, and dosing-day procedures in the required order.

2 roles · 1 guidelines · 0 courses · 0 providers

Overdose, misuse, and abuse-liability vigilance

Facilitators are expected to monitor for signs of misuse, diversion, dependence, or other abuse-related phenomena even though the medication is administered only on-site. They must also recognize protocol violations or dropout patterns that may signal abuse liability concerns.

1 role · 1 guidelines · 0 courses · 0 providers

Participant preparation and procedural guidance

Prepare participants for the dosing session and guide them through standardized procedures. The facilitator should ensure readiness, adherence to study rules, and smooth progression through the session schedule.

1 role · 1 guidelines · 0 courses · 0 providers

Participant preparation for medication adherence

Prepare participants to correctly use nicotine replacement therapy when assigned to the control arm. Facilitators must provide education, dosing instructions, and side-effect guidance.

2 roles · 1 guidelines · 0 courses · 0 providers

Pharmacokinetic literacy

Understands core pharmacokinetic concepts needed to interpret study findings and guide safety observation. Recognizes dose-linear exposure changes and elimination characteristics relevant to monitoring windows.

2 roles · 1 guidelines · 0 courses · 0 providers

Pre-session medical screening

The therapist/facilitator must ensure medical suitability before ayahuasca administration by checking for conditions that increase risk. Screening should include physical exam, laboratory testing, and pregnancy assessment when indicated.

2 roles · 1 guidelines · 0 courses · 0 providers

Preparation for ketamine sessions

Therapists must prepare participants psychologically and practically for ketamine dosing through rapport-building, psychoeducation, expectation-setting, and intention development. Preparation is emphasized because of trauma burden, psychiatric comorbidity, and instability in the target population.

1 role · 1 guidelines · 0 courses · 0 providers

Product identity verification

Verify the formulation and potency of the ibogaine product before administration. The manual warns that confusion between HCl, extract, and root bark can cause underdosing or fatal overdosing.

2 roles · 1 guidelines · 0 courses · 0 providers

Protocol adherence and dose conditions

Follows the study's operational rules for dose timing, progression, and stopping conditions. Reliable execution is necessary for both safety and interpretability of results.

2 roles · 1 guidelines · 0 courses · 0 providers

Provide structured psychological support alongside treatment

All patients in the trial received psychological support in conjunction with medication administration, indicating that facilitators must be able to deliver structured supportive care as part of the treatment model.

2 roles · 1 guidelines · 0 courses · 0 providers

Quetiapine XR augmentation management

Initiates, uptitrates, and monitors quetiapine XR augmentation in the comparator arm according to age-specific schedules and tolerability. Recognizes the therapeutic minimum and discontinuation triggers.

1 role · 1 guidelines · 0 courses · 0 providers

Reactivation event assessment

Identify and document possible post-dose reactivation or flashback-like experiences. The therapist must capture timing, context, emotional valence, and functional impact of these events.

1 role · 1 guidelines · 0 courses · 0 providers

Route-of-administration awareness

The facilitator should understand the administration context for the intervention. The source highlights inhalation as the studied route and its rapid onset.

1 role · 1 guidelines · 0 courses · 0 providers

Route-specific administration awareness

Facilitators need working knowledge of administration routes because onset, duration, intensity, and tolerability vary substantially. This informs preparation, monitoring, and participant education.

2 roles · 1 guidelines · 0 courses · 0 providers

Safety escalation and collaboration

Knows when to involve physicians, psychologists, and independent safety oversight. Complex psychedelic sessions require clear escalation pathways and team coordination.

1 role · 1 guidelines · 0 courses · 0 providers

Session-day eligibility and compliance checks

Clinicians must ensure participants meet day-of-session safety requirements before psilocybin is administered. This includes verifying toxicology, pregnancy, alcohol abstinence, and adherence to protocol restrictions.

2 roles · 1 guidelines · 0 courses · 0 providers

Structured smoking cessation treatment delivery

Facilitators must be able to deliver psilocybin only as an adjunct within a structured 15-week smoking cessation protocol rather than as a standalone intervention. This requires integrating psychedelic sessions with established tobacco cessation treatment methods.

1 role · 1 guidelines · 0 courses · 0 providers

Study design integrity

Supports rigorous conduct of randomized controlled safety studies by maintaining protocol adherence and minimizing bias. Protects the validity of safety, tolerability, and exploratory efficacy assessments.

2 roles · 1 guidelines · 0 courses · 0 providers

Subpsychedelic 5-MeO-DMT administration

Administers repeated sublingual microdoses of 5-MeO-DMT in a controlled clinical trial setting. Must follow the assigned dose schedule and maintain blinding across active and placebo conditions.

2 roles · 1 guidelines · 0 courses · 0 providers

Supervised at-home treatment oversight

Ability to support supervised at-home ketamine use when clinically appropriate. This implies monitoring and structure even outside the office setting.

1 role · 1 guidelines · 0 courses · 0 providers

Understand LSD dosing framework used in therapy

The intervention involved two dosing sessions with either low-dose or high-dose LSD, implying facilitators need knowledge of session-based LSD administration frameworks. This includes understanding that psychotherapy support is paired with specified dosing regimens.

1 role · 1 guidelines · 0 courses · 0 providers

Understand psilocybin-assisted therapy as a rapid-acting intervention for depression

Facilitators require knowledge of the therapeutic context, including that psilocybin is being investigated as a rapid-acting treatment for major depressive disorder. This includes understanding the expected timeframe of symptom assessment and response.

1 role · 1 guidelines · 0 courses · 0 providers

Understanding of bipolar-specific risk context

The facilitator must understand why bipolar II participants require enhanced monitoring and conservative dosing. The protocol is built around the risk of mood destabilization in this population.

1 role · 1 guidelines · 0 courses · 0 providers

Understanding of dose-response limitations

Recognize that current evidence does not establish the lowest effective or safest exposure for ibogaine. Facilitators must understand the uncertainty surrounding efficacy at reduced doses.

1 role · 1 guidelines · 0 courses · 0 providers

Use of cognitive and behavioral assessment domains

Understand the domains assessed in the Storyline psychiatric and neurological interviews and use this knowledge to support accurate administration and interpretation of study tasks. Domains include cognition, mood, homeostasis, social support, and psychosis/suicidality screening.

2 roles · 1 guidelines · 0 courses · 0 providers

Use of non-IV delivery model

Knowledge that KAP may be delivered without intravenous access and that non-IV office-based use is part of the described practice model. This reflects a shift from IV-only psychiatric use to broader administration approaches.

2 roles · 1 guidelines · 0 courses · 0 providers

Use self-directed enquiry

Help participants direct attention to their own present-moment internal experience and explore it from multiple perspectives. This is practiced in preparation and used to support participants if challenging material emerges during dosing.

2 roles · 1 guidelines · 0 courses · 0 providers

Vital sign and clinical observation awareness

Understand the expected acute physiological effects of BPL-003 and monitor for clinically meaningful changes. The facilitator should recognize that transient blood pressure and heart rate increases may occur.

1 role · 1 guidelines · 0 courses · 0 providers

Case-based practice, peer consultation, and professional learning community

Teaches applied competence through role play, case discussion, peer consultation, seminars, mentorship, and learning-community structures. The emphasis is translating theory into practice, receiving feedback, and developing reflective clinical judgment with peers.

7 roles · 0 guidelines · 8 courses · 7 providers

Neurobiology of non-ordinary states

Teaches the neurobiological basis of psychedelic and non-ordinary states, including default mode, salience, fear, and related brain-network models. The competency links altered-state phenomenology with therapeutic mechanisms and clinical implications.

4 roles · 0 guidelines · 4 courses · 4 providers

Ethics and ethical practice

Cluster covering 4 related competencies including: Ethical practice, Ethics in psychedelic care, Ethics and ethical practice.

6 roles · 0 guidelines · 4 courses · 3 providers

Clinical protocol literacy

Teaches practitioners to read and understand clinical protocols, treatment manuals, and evidence-based psychedelic care procedures. The focus is knowing how protocol requirements shape preparation, dosing, integration, documentation, and safety responsibilities.

6 roles · 0 guidelines · 2 courses · 2 providers

Preparation and therapeutic alliance

Cluster covering 2 related competencies including: Preparation and therapeutic alliance, Preparation and therapeutic alliance building.

3 roles · 0 guidelines · 2 courses · 2 providers

Dosing-session framework

Cluster covering 2 related competencies including: Dosing-session framework, Dosing-session framework use.

4 roles · 0 guidelines · 2 courses · 1 providers

Psilocybin prescribing fundamentals

Cluster covering 2 related competencies including: Psilocybin prescribing fundamentals, Prescribing fundamentals for psychedelic treatment.

2 roles · 0 guidelines · 2 courses · 1 providers

Active guiding and purposeful intervention

The course also teaches a more active guiding style, especially through Ralph Metzner’s approach, where guides may introduce focused inquiries, somatic practices, or other interventions. Learners are shown how interventions can shape the trajectory of a session when used skillfully.

3 roles · 0 guidelines · 1 courses · 1 providers

Apprenticeship and mentor shadowing

The program includes supervised apprenticeship hours with pre-approved mentors. Learners are expected to observe, assist, and translate training into supervised practice.

4 roles · 0 guidelines · 1 courses · 1 providers

Clinical trial training and feedback use

The page highlights best-in-class clinical training for drug trials and AI-supported evaluation. Learners are expected to refine skills quickly and receive targeted feedback in training or evaluation contexts.

6 roles · 0 guidelines · 1 courses · 1 providers

Collaborative-care role awareness

The program emphasizes that it prepares people for therapeutic and facilitative roles within a collaborative care framework, not independent medical practice. Learners are expected to understand role boundaries, especially around prescribing and administration.

5 roles · 0 guidelines · 1 courses · 1 providers

Compound comparison for therapeutic use

The course teaches learners to distinguish between classic psychedelics and emerging therapies within therapeutic applications. This is a foundational comparative literacy competency rather than a protocol-specific skill.

6 roles · 0 guidelines · 1 courses · 1 providers

Contemplative practice support

Contemplative practice is included as a core domain, suggesting learners are exposed to practices that support presence, reflection, and self-regulation in facilitation work. This likely supports both practitioner preparation and client-facing care.

3 roles · 0 guidelines · 1 courses · 1 providers

Expanded-state therapeutic skills

The course explicitly teaches techniques for working with patients in altered states, including grounding, breathwork, and mindfulness. These are presented as tools for supporting expanded and ordinary states of consciousness.

3 roles · 0 guidelines · 1 courses · 1 providers

Human-centred, experiential facilitation

The overall program emphasizes experiential, relational, and community-grounded learning, including retreat and practicum components. Learners are expected to develop a grounded facilitation presence in addition to theory.

3 roles · 0 guidelines · 1 courses · 1 providers

Microdosing and macrodosing protocol design

Learners are taught to design custom protocols for both microdosing and macrodosing based on client goals. The page also references microdosing formulas and practical application of timing and dosage nuances.

3 roles · 0 guidelines · 1 courses · 1 providers

Observing and holding space without reacting

Learners are expected to develop the ability to witness clients and processes calmly, without overreacting or trying to control the experience. The course explicitly frames this as foundational to practitioner development.

4 roles · 0 guidelines · 1 courses · 1 providers

Safety, ethics, and responsibility in expanded states work

The course explicitly states that facilitators are guided in safety, ethics, and responsibility. Learners are expected to recognize and manage the unique risks of working with altered states.

3 roles · 0 guidelines · 1 courses · 1 providers

Structured PAP process navigation

The course teaches the overall PAP workflow from screening through follow-up. Learners are expected to understand and explain each phase of treatment in a structured way.

4 roles · 0 guidelines · 1 courses · 1 providers

Supervised experiential practice

A defining feature of the training is hands-on experiential practice in both non-substance and substance-based modalities under supervision. Learners practice patient and therapist roles, facilitating and undergoing sessions in a structured learning context.

4 roles · 0 guidelines · 1 courses · 1 providers

Supervised practicum and feedback integration

Students complete 50 supervised practicum hours and receive expert feedback while working with real clients. This is intended to translate theory into competent applied practice.

4 roles · 0 guidelines · 1 courses · 1 providers

Supporting diverse spiritual and community contexts

The program states it prepares facilitators to address the needs of clients, patients, or community members from diverse faith traditions and communities of origin. Learners are expected to adapt facilitation to varied settings and worldviews.

3 roles · 0 guidelines · 1 courses · 1 providers

Tracking nervous systems and consent dynamics

The Colorado practicum site explicitly teaches relational competence, including tracking nervous systems, power, and consent dynamics moment by moment. This is presented as a core facilitation capability.

4 roles · 0 guidelines · 1 courses · 1 providers

Hybrid in-person and virtual session support

The course teaches students to guide both in-person and online sessions, including the technical skills needed for virtual facilitation. It explicitly notes that online training includes learning tech skills to become a confident virtual guide.

3 roles · 0 guidelines · 0 courses · 1 providers

Virtual safety and support management

The program states that the virtual training has been streamlined so students feel safe and supported no matter what arises. This signals competency in maintaining safety in online psychedelic support contexts.

3 roles · 0 guidelines · 0 courses · 1 providers

General psychedelic-assisted practice skills

Catch-all cluster covering 189 general competencies for psychedelic-assisted clinical practice that did not group into a more specific category — including miscellaneous facilitation, monitoring, ethics, safety, regulatory awareness, group support, and program-specific skills not captured by dedicated clusters elsewhere.

8 roles · 45 guidelines · 27 courses · 18 providers