Knowledge of psychedelic session structure

The manuals converge on the idea that psychedelic work depends on a clearly sequenced treatment structure. Across the extracts, there is shared emphasis on preparation before dosing, a facilitation or dosing phase, and integration or follow-up afterwards, with timing treated as part of safety and treatment delivery. They also agree that the sequence is not incidental, since the protocol is described as standardising participant experience and the psychotherapy framework is presented as shaping mindset, intention, and later assimilation of material. The sources differ in how much detail they give about timing and what that timing is used for. The comparative acute effects study focuses on substance-specific duration, onset, peak, and offset, noting that mescaline may need the longest observation and support, while LSD and psilocybin differ in duration. By contrast, the grief protocol and the psilocybin depression trial focus more on the broader therapeutic arc, including preparation, integration, baseline assessment, same-day dosing, and postdosing follow-up, rather than on comparative pharmacological timing. They also differ in emphasis on change processes. The grief protocol explicitly highlights post-treatment neuroplastic and psychological change windows and the role of integration in behaviour change, while the depression trial extract stresses standardisation of the participant experience and identical psychological support across arms.