Psilocybin psychotherapy framework

The manuals converge on psilocybin psychotherapy as a combined-modality framework, where psychotherapy is coordinated with dosing sessions rather than delivered as a medication-only intervention. Across the extracts, the treatment model includes structured preparation, medicine session support, and follow-up or integration, with an emphasis on fitting psychotherapy to the timing of the psychedelic intervention and maintaining continuity across phases of care. They also agree that facilitators need working knowledge of protocol structure, including dose timing, session sequencing, and the broader treatment platform. The sources repeatedly frame this as clinically informed support within a defined workflow, whether that is the three-stage preparation, facilitation, integration model, or a trial-specific schedule with multiple psychotherapy sessions around one or more psilocybin administrations. The manuals differ in clinical context and protocol design. One source centres the general psychedelic-assisted psychotherapy framework and the role of context, mindset, and post-treatment integration, while the others focus on specific psilocybin trials in life-threatening cancer, major depressive disorder, and alcohol use disorder. They also differ in dosing structure, from a single-dose intervention, to two doses one month apart, to doses at weeks 4 and 8 within a 12-week psychotherapy platform, with one trial using active placebo and double-blind randomisation.