United States

Key Insights

1
No psychedelic is broadly approved in the US for psychiatric use; esketamine is approved for treatment-resistant depression, while ketamine remains off-label and MDMA lacks FDA approval.
2
Blossom logs 488 US trials, 160 active, across 242 organisations; psilocybin, ketamine and placebo dominate, with LSD, ibogaine and MDMA still in active studies.
3
The US set the regulatory template in 2023, when the FDA issued its first draft guidance for clinical trials with psychedelic drugs.
4
Momentum is being driven by NIDA and the FDA: NIDA is expanding psychedelic funding, while the FDA’s 2024 MDMA advisory review signalled higher scrutiny, not retreat.

Medical Only (Private)

Reimbursed Care Access

In the United States, a limited medical framework exists for ketamine-derived treatments (FDA‑approved esketamine/SPRAVATO with REMS requirements and wide off‑label IV/IM ketamine use in private clinics), while classical psychedelics such as psilocybin and MDMA remain unapproved at the federal level but are the focus of advanced clinical trials and regulatory submissions. Most other compounds (DMT, 5‑MeO‑DMT, ibogaine, ayahuasca, mescaline, 2C‑X) are federally scheduled or controlled and have no authorized medical use outside approved research; access therefore is mainly via clinical trials or state/local policy experiments. [https://spravatorems.com|SPRAVATO REMS] [https://maps.org/2023/12/13/maps-celebrates-submission-of-new-drug-application-to-fda-for-mdma-assisted-therapy-for-ptsd/|MAPS NDA announcement] [https://www.forbes.com/sites/ajherrington/2025/08/23/dea-forwards-psilocybin-rescheduling-petition-to-hhs-for-review/|Forbes on psilocybin rescheduling action]

Full guide →

Quick Indicators

Active Trials

160

Total Trials

495

Organizations

831

Events

107

Reimbursement Guide→All Countries→Clinical Trials→Research Papers→

Organizations

100

Research Events

Clinical Trials

Active and completed clinical trials investigating psychedelic-assisted therapies in United States.

Not yet recruitingPhase I/II

Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder

Started: August 1, 2026

Not yet recruitingPhase I

Psilocybin After Trauma Surgery for Pain

Started: July 1, 2026

Not yet recruitingPhase II

Anesthesia-Masked Psilocybin Therapy for Major Depression

Started: July 1, 2026

Not yet recruitingPhase I

Shortened LSD Intervention for Major Depressive Disorder

Started: July 1, 2026

Not yet recruitingPhase II

Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers

Started: June 15, 2026

Not yet recruitingPhase III

Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

Started: June 1, 2026

United States

Key Insights

Reimbursed Care Access

Quick Indicators

Organizations

2nd Chance

A Mind's Journey

A Mindful Path

A Nourished Mind

AIM Youth Mental Health

AIMS Institute

AMG Ketamine and Wellness Center

APS Ketamine

AbbVie

Absolute Rehabilitation

Achieve Medical / SokyaHealth

Acute Pain Therapies

Advanced Brain and Body Clinic

Advanced Infusion and Wellness Center

Advanced Integrative Medical Science Institute

Advanced Ketamine Associates

Advanced Pain Relief Institute

Advanced Psychiatric Solutions

Advanced Psychiatric Solutions of Kansas City

Advanced Psychiatry of Elgin

Advanced Rejuvenation

Advanced TMS Center

Advanced Wellness and Pain

Advantage Infusions

Aetna

Alabama Ketamine Clinics

Albany Ketamine Infusions

Alchemy

Alchemy Wellness

Alex Criddle

All Points North

All Psychedelic Health

Allay Health & Wellness

Allegra Family Clinic

Alma Institute

Alpine Health and Wellness

Altasano Infusion Center

Altered States Integration

America's Poison Centers

American Academy of Child Adolescent Psychiatry.

American Foundation for Suicide Prevention

American Psychiatric Association

An Enduring Love

Andala

Andersons Clinic

Anew Clinical Practitioners

Anne and Don Fizer Foundation

Anodyne Headache and PainCare

Antonio Cubano

Apex Health Alliance Ketamine Therapy

Apollo Neuroscience, Inc.

Archeron Center for Psychiatric Healing

Arizona Biomedical Research Commission (ABRC)

Arizona Infusion

Arizona Ketamine Specialists

Arizona Ketamine Treatment and Research Institute

Arizona Pain Care

Arthritis Relief Institute

Ascend Health Center

Ascent Mental Health

Aspen Comprehensive Health Interventions

Aspen Ketamine Center

AtaiBeckley

Atlanta Center for Ketamine Treatment

Austin Ketamine Clinic

Austin Ketamine Specialists

Autism Psychedelic Community

Avadel CNS Pharmaceuticals, LLC

Awaken Aba

AyaFusion Wellness Clinic

Ayahuasca Healings

Ayahuasca Wisdom

Balance Ketamine Clinics

Balanced Mental Wellness

Ballard Psychiatry