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ACS Chemical Neuroscience

21 Papers Indexed in Blossom

Published Papers

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Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics

This rat study found that zalsupindole (third-generation psychedelic) produced robust effects on structural and functional neuroplasticity in the prefrontal cortex as well as sustained antidepressant-like responses comparable to or greater than those of ketamine, psilocybin, and DMT, despite lacking any of the acute cellular and behavioural characteristics of hallucinogenic or dissociative compounds.

Published
Journal
ACS Chemical Neuroscience
Authors
Agrawal, R., Gillie, D., Mungenast, A., Chytil, M., Engel, S., Wu, M. C., Rasmussen, K., Salinas, E., Olson, D. E.
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Effects of a Serotonergic Psychedelic on the Lipid Bilayer

This lab study used different ways of looking at cells to see how the psychedelic drug DOI affects the outer layer of cells (lipid membrane). The study found that DOI is over 100 times stronger than serotonin at disrupting the cell's outer layer, helping small bubble-like structures combine with cells, and making it easier for tiny holes to form in cell membranes. This suggests that psychedelics might affect the brain not just by binding to receptors (their usual known method), but also by physically changing how cell membranes work and help create new connections.

Published
Journal
ACS Chemical Neuroscience
Authors
Saha, D., Singh, A., Vaidya, V. A., Huster, D., Mote, K. R., Maiti, S.
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Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A

This fMRI study explores the effects of psilocybin (a serotonergic psychedelic) and Salvinorin-A (a kappa-opioid receptor agonist) on resting-state functional connectivity (FC) in nonhuman primates. It reveals both drugs influence FC around the thalamus, claustrum, prefrontal cortex (PFC), and default mode network (DMN), with similarities and differences noted between them.

Published
Journal
ACS Chemical Neuroscience
Authors
Bagdasarian, F. A., Hansen, H. D., Chen, J., Yoo, C. H., Placzek, M. S., Hooker, J. M., Wey, H. Y.
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Effects of external stimulation on psychedelic state neurodynamics

This further analysis of data from a single-blind, placebo-controlled study (n=20) on the effects of LSD (75µg) finds that the context (eyes closed/open, silence/music/video) modulates the level of brain entropy. The study finds that eyes-closed elicited the biggest response, and that video (external stimuli) disrupts the correlation between brain entropy and subjective ratings of the experience.

Published
Journal
ACS Chemical Neuroscience
Authors
Mediano, P. A. M., Rosas, F. E., Timmermann, C., Roseman, L., Nutt, D. J., Feilding, A., Kaelen, M., Kringelbach, M. L., Barrett, A. B., Seth, A. K., Muthukumaraswamy, S., Bor, D., Carhart-Harris, R. L.
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Neuroplasticity: The Continuum of Change

This viewpoint (2023) explores the concept of neuroplasticity, which is increasingly used in mainstream discourse to describe how the brain responds to various stimuli. Neuroplasticity is a complex concept encompassing molecular, cellular, and circuit-level changes and their impact on human behaviour. The article aims to comprehensively understand neuroplasticity by engaging experts from various scientific disciplines. It emphasizes its relevance in healthy and diseased conditions, highlighting its importance in chemical neuroscience.

Published
Journal
ACS Chemical Neuroscience
Authors
Wallace, R. M., Olson, D. E., Hooker, J. M.
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5-HT2ARs Mediate Therapeutic Behavioral Effects of Psychedelic Tryptamines

This rodent study suggests that activating serotonin 2A receptors is essential for tryptamine-based psychedelics to produce antidepressant-like effects in rodents. The study also suggests that psychedelic tryptamines can induce hallucinogenic and therapeutic effects through activation of the same receptor. It highlights the need for full mechanistic understanding of how these molecules produce therapeutic effects.

Published
Journal
ACS Chemical Neuroscience
Authors
Cameron, L. P., Patel, S. D., Vargas, M. V., Barragan, E. V., Saeger, H. N., Warren, H. T., Chow, W. L., Gray, J. A., Olson, D. E.

Quick Facts

Papers Indexed
21
h-Index
104
Open Access
No
Publisher
American Chemical Society
Country
United States
Website
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