American Journal of Translational Research

Single low-dose esketamine improves postpartum depression symptoms and recovery quality in cesarean section women

This randomised controlled trial (n=136) found that a single low-dose esketamine infusion (14mg/70kg) given after fetal delivery during caesarean section, combined with patient-controlled analgesia, reduced postnatal depression scores at days 2 and 7, improved recovery quality, and shortened time to first ambulation, flatus and breastfeeding compared to placebo, with no significant difference in adverse events.

Published

February 15, 2026

Journal

American Journal of Translational Research

Authors

Jing, R., Tu, Y.