Back to journals
Academic Journal

Anesthesiology

2 Papers Indexed in Blossom

Published Papers

Paywallindividual

(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function

This rodent study (2014) argues that a full analysis of (R,S)-ketamine's metabolites is required to understand ketamine's anti-depressive and analgesic effects.

Published
Journal
Anesthesiology
Authors
Paul, R. K., Singh, N. S., Khadeer, M., Sanghvi, M., Green, C. E., O'loughlin, K., Torjman, M. C., Bernier, M., Wainer, I. W.
Open Accessindividual

Psychedelic Effects of Ketamine in Healthy Volunteers: Relationship to Steady-state Plasma Concentrations

This crossover study of healthy volunteers (n=10) given computer-assisted continuous infusions, subanaesthetic ketamine (50–200 ng/ml steady-state plasma concentrations) produced dose-related psychedelic effects. Subjective ratings (VAS and the Hallucinogen Rating Scale) correlated highly linearly with venous ketamine concentrations (R ≈ 0.93–0.99 for VAS; overall plasma-target correlation R = 0.997) and yielded HRS scores comparable to those seen with DMT.

Published
Journal
Anesthesiology
Authors
Bowdle, A. T., Radant, A. D., Cowley, D. S., Kharasch, E. D., Strassman, R. J., Roy-Byrne, P. P.

Quick Facts

Papers Indexed
2
h-Index
277
Open Access
No
Publisher
Wolters Kluwer
Country
United States
Website
Visit