This cell-based (in vitro) study investigated how the cytochrome P450 (CYPs) enzymes contribute to the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD and its potential for clinical LSD use. The study found that the human liver converted only small quantities of LSD to nor-LSD and O-H-LSD, however, several CYPs substantially contributed to the process. The review concluded that there is a link between genetic polymorphisms and drug interactions and it could therefore affect the pharmacodynamics and pharmacokinetics of LSD. Also, it was found that nor-LSD potentially may have hallucinogenic activity similar to LSD, while O-H-LSD is inactive.
- Published
- Journal
- Biochemical Pharmacology
- Authors
- Luethi, D., Hoener, M. C., Krähenbühl, S., Liechti, M. E., Duthaler, U.