This review (2014) examines the commonalities and differences across hallucinations occurring in schizophrenia and in response to psychostimulants, psychedelics, and dissociative anesthetics. They identify three principal pharmacological mechanisms activation of dopamine D2 receptors (D2Rs) with psychostimulants, (2) activation of serotonin 5HT2A receptors (HT2ARs) with psychedelics, and (3) blockage of glutamate NMDA receptors (NMDARs) with dissociative anesthetics, each of which explains different aspects of clinically observed hallucinations amongst patients with schizophrenia.
- Published
- Journal
- BioMed Research International
- Authors
- Amad, A., Bordet, R., Cottencin, O., Jardri, R., Rolland, B., Thomas, P.