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40 Papers Indexed in Blossom

Published Papers

Open Accessindividual

LSD persistently disrupts affective pain processing

This rat study found that a single dose of LSD persistently reduced the emotional, rather than sensory, aspect of pain. The effect was linked to the anterior cingulate cortex, where LSD dampened pain-related brain responses and reduced encoding of aversive value.

Published
Journal
Biorxiv
Authors
Plotkin, J., Zhu, E., Druart, M., Zhang, Q., Hu, E., Cathcart, D., Jun, N., Kwok, L., Sippy, T., Wang, J.
Open Accessmeta

Characterizing Resting-State Brain Dynamics with Frequency-Resolved EEG Microstates: Parallel Analyses of Psilocybin Microdosing and Acute Inhaled DMT

This brain imaging secondary analysis of two studies compared resting-state EEG microstate patterns during psilocybin microdosing and acute inhaled DMT, and found that frequency-specific analysis picked up changes that broadband analysis sometimes missed. Psilocybin microdosing had subtle effects, while DMT produced broader shifts in brain activity patterns.

Published
Journal
Biorxiv
Authors
Tarailis, P., Griskova-Bulanova, I.
Open Accessindividual

Serotonergic Polypharmacology of 2-Halogenated Tryptamines

This mouse study found that 2-halogenated tryptamine derivatives of DMT and psilocybin had reduced activity at receptors linked to psychedelic effects and heart-related risks, while keeping strong activity at 5-HT6 receptors. In mice, 2-Br-psilacetin did not trigger the usual head-twitch response and showed some improvements in stress-related behaviour and cued learning.

Published
Journal
Biorxiv
Authors
Yacoub, J., Bray, E., Bayyat, J., Glatfelter, G. C., Leake, A., Buitrago, E. M., Maitland, A. D., Partilla, J., Cavalco, N. G., Schalk, S. S., Lammers, J. C., Baumann, M. H., McCorvy, J., Leahy, J. W., Gulick, D., Witowski, C. G., von Salm, J. L.
Open Accessindividual

Psilocybin reshapes cortical inhibition through selective interneuron recruitment

This mouse study found that psilocybin changes inhibitory signalling in the medial frontal cortex by reducing the activity of somatostatin interneurons and increasing parvalbumin interneuron activity. The effects appear to act through 5-HT1A receptors on somatostatin cells and may contribute to psilocybin’s longer-lasting behavioural effects.

Published
Journal
Biorxiv
Authors
Davoudian, P. A., Jiang, Q., Knox, C. A., Savalia, N. K., Shao, L. X., Wilson, J., Weiner, A. M., Chong, C. W., Liao, C., Nothnagel, J. D., Sakurai, T., Kwan, A. C.
Open Accessindividual

Dissociating the Hallucinogenic and Neuroplastic Effects of Psilocybin

This cell study found that psilocybin increased the formation and maturation of new synapses while speeding up the loss of existing ones. It also showed that serotonin 2A receptors in a specific cortical neuron type were needed for these neuroplastic changes but not for hallucination-like effects.

Published
Journal
Biorxiv
Authors
Baker, J. J., Kogan, E., Lu, J., Zuo, Y.
Open Accessindividual

A multi-institutional investigation of psilocybin's effects on mouse behavior

In a coordinated five‑laboratory study of ~200 mice, psilocybin (2 mg/kg IP) produced robust, replicable acute behavioural effects — increased anxiety- and avoidance-related behaviour and reduced fear expression — but did not reproducibly produce persistent (24 h) anxiolytic, antidepressant, fear‑extinction or pro‑social effects. The multi‑institutional design therefore both delineates the reliable acute actions of psilocybin and provides a model for improving reproducibility in psychedelic research.

Published
Journal
Biorxiv
Authors
Lu, O. D., White, K., Raymond, K., Liu, C., Klein, A. S., Green, N., Vaillancourt, S., Gallagher, A., Shindy, L., Li, A., Wallquist, K., Li, R., Zou, M., Casey, A. B., Cameron, L. P., Pomrenze, M. B., Sohal, V., Kheirbek, M. A., Gomez, A. M., Lammel, S., Heifets, B. D., Malenka, R.

Quick Facts

Papers Indexed
40
Publisher
openRxiv
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