Tryptamine

5-MeO-DMT

A potent tryptamine psychedelic known for profound mystical experiences, currently under clinical investigation for TRD and anxiety.

Pharmacology & Mechanism of 5-MeO-DMT

Detailed pharmacological information is currently being assembled by our research team.

Quick Facts

  • Highest PhasePhase II
  • Key IndicationsTreatment-Resistant Depression (TRD), Alcohol Use Disorder (AUD)
  • Primary Mechanism5-HT2A / 5-HT1A Agonist
  • Session Duration20-45 minutes
  • OriginZoological (Bufo) / Botanical / Synthesised

Connected Research

Recent clinical trials and academic literature investigating 5-MeO-DMT.

Recent Clinical Trials

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CompletedPhase I/II

Efficacy of Sublingual 5-MeO-DMT for Reducing Anxiety and Depression in MCI (5-MeO-DMT)

CompletedPhase I/II

Safety, Tolerability, and Efficacy of Sublingual Microdoses of 5-MeO-DMT for Depression and Anxiety (5-MeO-DMT)

WithdrawnPhase II

Trifecta Research Study

CompletedPhase II

A Trial of GH001 in Patients With Treatment-resistant Depression

CompletedPhase II

An Open-Label, Single Dose Study in Patients With Alcohol Use Disorder

CompletedPhase I

Pharmacokinetics, Safety, and Tolerability of Intramuscular 5-MeO-DMT in Healthy Volunteers

Recent Academic Papers

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Complex slow waves in the human brain under 5-MeO-DMT

Published
Journal
Cell Reports

Safety and tolerability of multiple sublingual microdoses of 5-MeO-DMT in adults with moderate symptoms of depression and/or anxiety: a randomized, double-blind, placebo-controlled study

Published
Journal
Neuropsychopharmacology

Health-related behavioral changes following the use of psychedelics in naturalistic settings

Published
Journal
Preventative Medicine Reports

Evaluation of the peak experience scale as a rapid assessment tool for the strength of a psychoactive experience with 5-MeO-DMT

Published
Journal
Frontiers in Psychology

Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness

Published
Journal
Neuroscience of Consciousness

Insights on Psychedelics: A Systematic Review of Therapeutic Effects

Published
Journal
Neuroscience and Biobehavioral Reviews