Effects of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) administered by intramuscular injection on frequency oscillatory power bands in healthy adults

Fifteen healthy volunteers will attend four dosing days spaced two weeks apart in a single-group, non-randomised, single-blind design; each session involves a single IM administration of 5‑MeO‑DMT (3 mg, 6 mg or 9 mg) or inactive saline.

Primary assessments are MEG-derived frequency oscillatory power bands (eyes closed) and post-acute fMRI functional connectivity measured ~90 minutes post-dose (12-minute resting-state MEG and 6-minute anatomical/functional MRI acquisitions).