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6 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Complex slow waves in the human brain under 5-MeO-DMT

This naturalistic EEG study (n=29) examines the effects of inhaled synthetic 5-MeO-DMT (12mg) on brain activity in healthy individuals. It finds that 5-MeO-DMT radically reorganises low-frequency neural activity flows, making them incoherent, heterogeneous, and nonrecurring. It also causes broadband activity to exhibit slower, more stable, low-dimensional behaviour with increased energy barriers to rapid global shifts.

Published
Journal
Cell Reports
Authors
Blackburne, G., Mcalpine, R. G., Fabus, M., Liardi, A., Kamboj, S. K., Mediano, P. A. M., Skipper, J. I.
Open Accessindividual

A non-hallucinogenic LSD analog with therapeutic potential for mood disorders

This mice and cell study of the non-hallucinogenic LSD analogue 2-bromo-LSD (2-Br-LSD) found it to be a partial agonist at the 5-HT2A receptor but it doesn't activate the 5-HT2B receptor associated with cardiac valvulopathy (disease of heart valves). It also does not induce tolerance and has been shown to promote neuronal structural plasticity and active coping behaviour in mice. Additionally, 2-Br-LSD reverses the effects of chronic stress. These findings suggest that 2-Br-LSD may have therapeutic potential for mood disorders and other indications.

Published
Journal
Cell Reports
Authors
Lewis, V., Bonniwell, E. M., Lanham, J. K., Halberstadt, A. L., Aguilar-Valles, A., Mccorvy, J. D., Ghaffari, A., Sheshbaradaran, H., Cao, A. B., Calkins, M. M., Bautista-Carro, M. A., Arsenault, E., Telfer, A., Taghavi-Abkuh, F. F., Malcolm, N. J., Sayegh, F. E., Abizaid, A., Schmid, Y., Morton, K.
Open Accessindividual

Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

This rodent study investigated the biological substrates of the enduring effects of the psychedelic DOI on the frontal cortex. It finds that a single dose produced rapid structural changes in dendritic spines and sustained alterations in chromatin organisation related to synaptic plasticity, potentially explaining long-lasting antidepressant actions.

Published
Journal
Cell Reports
Authors
De La, M., Revenga, F., Zhu, B., Guevara, C. A., Huntley, G. W., Lu, C., Gonza ´lez-Maeso, J., De La Fuente Revenga, M., Naler, L. B., Saunders, J. M., Zhou, Z., Toneatti, R., Sierra, S., Wolstenholme, J. T., Beardsley, P. M.
Open Accessindividual

LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions

This rat study investigated the neural correlates of LSD-induced abnormal perceptions while animals navigated a familiar track. It finds that LSD suppresses hippocampal-cortical interactions and degrades internal spatial representations, isolating them from external sensory input, which may underlie the phenomenon of hallucinations.

Published
Journal
Cell Reports
Authors
Domenico, C., Haggerty, D., Mou, X., Ji, D.
Open Accessindividual

A dynamic and multilocus metabolic regulation strategy using quorum-sensing-controlled bacterial small RNA

This in vitro study (2021) developed a novel method of transcriptional gene repression within E. coli that increased the yield of psilocybin biosynthesis by 302.9% without affecting cell growth.

Published
Journal
Cell Reports
Authors
Bao, S. H., Jiang, H., Zhu, L. Y., Zhang, Z. Y., Zhang, D. Y., Meng, E., Yao, G., Han, P. G., Wan, X. K., Wang, K., Song, T. Y., Liu, C. J., Wang, S.
Open Accessindividual

Psychedelics promote structural and functional neural plasticity

This cell (in vitro) and animal (in vivo, larvae & rats) study shows the various ways (stimulation of the TrkB, mTOR, and 5-HT2A signaling pathways) through which psychedelics promote/increase plasticity in the brain.

Published
Journal
Cell Reports
Authors
Ly, C., Greb, A. C., Cameron, L. P., Wong, J. M., Barragan, E. V., Wilson, P. C., Burbach, K. F., Zarandi, S. S., Sood, A., Paddy, M. R., Duim, W. C., Dennis, M. Y., Mcallister, A. K., Ori-Mckenney, K. M., Gray, J. A., Olson, D. E.

Quick Facts

Papers Indexed
6
h-Index
246
Open Access
Yes
Publisher
Elsevier
Country
Netherlands
Website
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