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Academic Journal

Clinical Pharmacokinetics

3 Papers Indexed in Blossom

Published Papers

Paywallindividual

Pharmacokinetics, Pharmacodynamics, and Urinary Recovery of Oral Mescaline Hydrochloride in Healthy Participants

This pharmacokinetic-pharmacodynamic analysis (n=46) of two Phase I trials of oral mescaline (100-800 mg) showed dose-proportional exposure with peak concentrations at 2 hours, a half-life of 3.5 hours, onset of effects around 1 hour post-dose, maximum effect intensity and duration ranging from 13% and 2.8 hours (100 mg) to 89% and 15 hours (800 mg), with 53% urinary excretion unchanged and 31% as the main metabolite, indicating at least 53% oral bioavailability.

Published
Journal
Clinical Pharmacokinetics
Authors
Mueller, L., Klaiber, A., Ley, L., Becker, A. M., Thomann, J., Luethi, D., Schmid, Y., Liechti, M. E.
Open Accessindividual

Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults

This open-label study (n=12) gave healthy participants increasing doses of psilocybin (21-42mg/70kg). The study found the half-life to be about 3 hours, this was not predicted by body weight, and no adverse effects were observed.

Published
Journal
Clinical Pharmacokinetics
Authors
Brown, R. T., Nicholas, C. R., Cozzi, N. V., Gassman, M. C., Cooper, K. M., Muller, D., Thomas, C. D., Hetzel, S. J., Henriquez, K. M., Ribaudo, A. S., Hutson, P. R.
Open Accessindividual

Pharmacokinetics and pharmacodynamics of lysergic acid diethylamide in healthy subjects

This analysis of data from two double-blind, placebo-controlled studies (n=40) on the pharmacokinetics of LSD (100 and 200µg) found dose-proportional effects. The effects lasted on average 8.2 and 11.6 hours, there was a strong correlation between the blood-plasma level of LSD and subjective effects, but this was only found within-subjects (over time), not between subjects.

Published
Journal
Clinical Pharmacokinetics
Authors
Dolder, P. C., Schmid, Y., Steuer, A. E., Kraemer, T., Rentsch, K. M., Hammann, F., Liechti, M. E.

Quick Facts

Papers Indexed
3
h-Index
191
Open Access
No
Publisher
Adis International
Country
Switzerland
Website
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