Decomposing fMRI into connectome harmonics, the authors show that multi-scale structure–function coupling is a generalisable marker of consciousness: it increases during loss of consciousness (anaesthesia or brain injury)—distinguishing behaviourally indistinguishable patient subgroups and indexing covert consciousness—while LSD and ketamine produce the opposite decoupling that correlates with physiological and subjective measures.
- Published
- Journal
- Communications Biology
- Authors
- Luppi, A. I., Vohryzek, J., Kringelbach, M. L., Mediano, P. A. M., Craig, M. M., Adapa, R., Carhart-Harris, R. L., Roseman, L., Pappas, I., Peattie, A. R. D., Manktelow, A. E., Sahakian, B. J., Finoia, P., Williams, G. B., Allanson, J., Pickard, J. D., Menon, D. K., Atasoy, S., Stamatakis, E. A.