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Communications Biology

4 Papers Indexed in Blossom

Published Papers

Open Accessmeta

Psilocybin shapes the slow, global propagation of brain activity over the cortical layout of 5HT2a receptors

This brain imaging analysis (n=7) used fMRI data from sessions with psilocybin and a methylphenidate (Ritalin) control to explore how psychedelics affect the speed at which activity travels across the cortex. It found that faster propagation was linked to increased functional connectivity and that the distribution of 5-HT2a receptors may help explain how psilocybin modulates these travelling waves.

Published
Journal
Communications Biology
Authors
Mäki-Marttunen, V.
Open Accessindividual

Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience

This re-analysis (n=14) applies a receptor-informed network control theory framework to investigate the effects of DMT on the brain's control energy landscape. It reveals that DMT, like LSD and psilocybin, reduces global control energy, with these trajectories correlating with EEG signal diversity and subjective intensity ratings. Furthermore, the regional effects of DMT correlate with serotonin 2a receptor density, demonstrating a potential proof-of-concept for predicting pharmacological intervention effects on brain dynamics using control models.

Published
Journal
Communications Biology
Authors
Singleton, S. P., Timmermann, C., Luppi, A. I., Eckernäs, E., Roseman, L., Carhart-Harris, R. L., Kuceyeski, A.
Open Accessindividual

Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT)

Using a time-dependent whole-brain model parametrised by DMT pharmacokinetics, the authors show that intravenous DMT transiently moves the brain toward a global bifurcation, producing a brief increase in network reactivity concentrated in fronto‑parietal and visual cortices that correlates with 5‑HT2A receptor density. This provides a mechanistic account of the psychedelic state and predicts that its temporal evolution tracks DMT pharmacokinetics.

Published
Journal
Communications Biology
Authors
Piccinini, J. I., Perl, Y. S., Pallavicini, C., Deco, G., Kringelbach, M. L., Nutt, D. J., Carhart-Harris, R. L., Timmermann, C., Tagliazucchi, E.
Open Accessmeta

Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

Decomposing fMRI into connectome harmonics, the authors show that multi-scale structure–function coupling is a generalisable marker of consciousness: it increases during loss of consciousness (anaesthesia or brain injury)—distinguishing behaviourally indistinguishable patient subgroups and indexing covert consciousness—while LSD and ketamine produce the opposite decoupling that correlates with physiological and subjective measures.

Published
Journal
Communications Biology
Authors
Luppi, A. I., Vohryzek, J., Kringelbach, M. L., Mediano, P. A. M., Craig, M. M., Adapa, R., Carhart-Harris, R. L., Roseman, L., Pappas, I., Peattie, A. R. D., Manktelow, A. E., Sahakian, B. J., Finoia, P., Williams, G. B., Allanson, J., Pickard, J. D., Menon, D. K., Atasoy, S., Stamatakis, E. A.

Quick Facts

Papers Indexed
4
h-Index
91
Open Access
Yes
Publisher
Nature Portfolio
Country
United States
Website
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