This open-label study (n=19) found that 10mg oral psilocybin produced a significant reduction in OCD symptoms compared to 1mg, with a large effect size (Cohen's d = 0.82) one week after dosing, particularly for compulsions rather than obsessions, though effects diminished over subsequent weeks.
- Published
- Journal
- Comprehensive Psychiatry
- Authors
- Pellegrini, L., Fineberg, N. A., O'Connor, S., Pereira De Souza, A. M. F. L., Godfrey, K., Reed, S., Peill, J. M., Healy, C. J., Rohani-Shukla, C., Lee, H., Carhart-Harris, R. L., Robbins, T. W., Nutt, D. J., Erritzoe, D.